{"id":"a2621b7f-a348-57f0-9d60-54e9030713f4","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-beriberi-vascular-resistance","predicate":"repletion_increases_in_case","statement":"In the second patient, systemic vascular resistance rose within one to two hours after intravenous thiamine as cardiac output fell.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f8e56d21-0ae3-592f-9af1-eeaba69f030f","mechanism_event_label":"The abnormal circulation involved the blood vessels as well as the heart.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"77c2fd4c-d053-5963-b17b-12750eb06f33","slug":"systemic-vascular-resistance","display_name":"Systemic vascular resistance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f8e56d21-0ae3-592f-9af1-eeaba69f030f","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-beriberi-vascular-resistance-event","event_type":"observed_intervention","label":"The abnormal circulation involved the blood vessels as well as the heart.","description":"In the second patient, systemic vascular resistance rose within one to two hours after intravenous thiamine as cardiac output fell.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e69dfe38-3cee-530b-a11c-facdf5f2439d","slug":"cardiac-output","display_name":"Cardiac output","entity_type_key":"cellular_process"},"role":"parallel_endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"77c2fd4c-d053-5963-b17b-12750eb06f33","slug":"systemic-vascular-resistance","display_name":"Systemic vascular resistance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Serial measurements in one of the two cases.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No specific endothelial receptor, nitric oxide pathway or direct ATP mediator was isolated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The abnormal circulation involved the blood vessels as well as the heart.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic vasculature","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"dd4d2ce2-8be6-5a40-8a90-75b68e917d51","evidence_kind":"source_excerpt","locator":"Lines 1575-1585","start_line":1575,"end_line":1585,"excerpt":"### b1-beriberi-vascular-resistance\nIn the second patient, systemic vascular resistance rose within one to two hours after intravenous thiamine as cardiac output fell.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The abnormal circulation involved the blood vessels as well as the heart.\norganism: Homo sapiens\ntissue_or_cell_type: Systemic vasculature\nexperimental_model: Serial measurements in one of the two cases.\nlimitations: No specific endothelial receptor, nitric oxide pathway or direct ATP mediator was isolated.\nexposure: Study-specific exposure described in the model; no regimen inferred beyond the accessed evidence.\n[b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25","model_system":"Serial measurements in one of the two cases.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-byrne-quinn1969] Beriberi heart disease in London (1969). https://pubmed.ncbi.nlm.nih.gov/5822083/ DOI: 10.1136/bmj.4.5674.25","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}