Component
Candida albicans mitotic spindle assembly
Candida albicans mitotic spindle assembly. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Cinnamaldehyde at the reported MIC of 112 micrograms/mL completely inhibited Candida mitotic spindle assembly.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ceylon-research/29456868.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2", "start_char": 0, "end_char": 1751, "text_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2"}
- experimental_model
- Cultured yeast imaging, viability and cell-wall mutant assays
- exposure
- Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL
- limitations
- In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition.
- nutrient_topic
- Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
- organism
- Candida albicans RSY150 and clinical isolates
- plain_language
- At this assay concentration the fungus could not assemble its normal division machinery.
- primary_references
- [ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. (2018). https://pubmed.ncbi.nlm.nih.gov/29456868/ DOI: 10.1186/s40694-018-0046-5
- tissue_or_cell_type
- Fungal cell wall, membrane and mitotic spindle
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 987–998
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cultured yeast imaging, viability and cell-wall mutant assays · source_derived_draft · unverified_draft
### ceylon-candida-spindle Cinnamaldehyde at the reported MIC of 112 micrograms/mL completely inhibited Candida mitotic spindle assembly. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: At this assay concentration the fungus could not assemble its normal division machinery. organism: Candida albicans RSY150 and clinical isolates tissue_or_cell_type: Fungal cell wall, membrane and mitotic spindle experimental_model: Cultured yeast imaging, viability and cell-wall mutant assays limitations: In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition. exposure: Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL evidence_span: {"source_cache": "artifacts/ceylon-research/29456868.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2", "start_char": 0, "end_char": 1751, "text_sha256": "a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2"} [ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. (2018). https://pubmed.ncbi.nlm.nih.gov/29456868/ DOI: 10.1186/s40694-018-0046-5
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.