{"id":"3d856062-358b-55ba-a9b2-31997af28e33","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-candida-spindle","predicate":"disrupts","statement":"Cinnamaldehyde at the reported MIC of 112 micrograms/mL completely inhibited Candida mitotic spindle assembly.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43b974af-f4b0-5013-8cb5-7fca2f54ea05","mechanism_event_label":"At this assay concentration the fungus could not assemble its normal division machinery.","subject":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"object":{"id":"cd6d8a57-fded-5c4a-a004-7ce14923e99b","slug":"candida-mitotic-spindle-assembly","display_name":"Candida albicans mitotic spindle assembly","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"43b974af-f4b0-5013-8cb5-7fca2f54ea05","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-candida-spindle-event","event_type":"biochemical_relationship","label":"At this assay concentration the fungus could not assemble its normal division machinery.","description":"Cinnamaldehyde at the reported MIC of 112 micrograms/mL completely inhibited Candida mitotic spindle assembly.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cd6d8a57-fded-5c4a-a004-7ce14923e99b","slug":"candida-mitotic-spindle-assembly","display_name":"Candida albicans mitotic spindle assembly","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/29456868.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2\", \"start_char\": 0, \"end_char\": 1751, \"text_sha256\": \"a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured yeast imaging, viability and cell-wall mutant assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Candida albicans RSY150 and clinical isolates","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"At this assay concentration the fungus could not assemble its normal division machinery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. (2018). https://pubmed.ncbi.nlm.nih.gov/29456868/ DOI: 10.1186/s40694-018-0046-5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fungal cell wall, membrane and mitotic spindle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b645c582-ccd5-5e0b-9eb2-c7a243b778de","evidence_kind":"source_excerpt","locator":"Lines 987-998","start_line":987,"end_line":998,"excerpt":"### ceylon-candida-spindle\nCinnamaldehyde at the reported MIC of 112 micrograms/mL completely inhibited Candida mitotic spindle assembly.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: At this assay concentration the fungus could not assemble its normal division machinery.\norganism: Candida albicans RSY150 and clinical isolates\ntissue_or_cell_type: Fungal cell wall, membrane and mitotic spindle\nexperimental_model: Cultured yeast imaging, viability and cell-wall mutant assays\nlimitations: In-vitro antifungal activity is not clinical eradication; fungal spindle effects do not establish equivalent mammalian tubulin inhibition.\nexposure: Oil including subinhibitory 62.5 micrograms/mL; cinnamaldehyde MIC 112 micrograms/mL\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/29456868.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2\", \"start_char\": 0, \"end_char\": 1751, \"text_sha256\": \"a42223fd2d170b3cba7a0d3ab2670bb33bde4e05c1be831f6ebac45c66ecbce2\"}\n[ceylon-p29456868] Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans. 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