Component
Campylobacter jejuni carboxyspermidine decarboxylase
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Polyamine-auxotrophic Campylobacter deletion strains grew poorly; supplied related polyamines could rescue growth.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Bacterial culture; homospermidine and, less strongly, norspermidine rescue.
- limitations
- Do not turn a bacterial growth result into a human infection-risk estimate.
- nutrient_topic
- Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
- plain_language
- Polyamines can support microbial growth, including a pathogen.
- primary_references
- Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22025614/ · DOI 10.1074/jbc.M111.307835
Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 422–428
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Bacterial culture; homospermidine and, less strongly, norspermidine rescue. · source_derived_draft · unverified_draft
## spermidine-microbial-growth Polyamines can support microbial growth, including a pathogen. Polyamine-auxotrophic Campylobacter deletion strains grew poorly; supplied related polyamines could rescue growth. Model: Bacterial culture; homospermidine and, less strongly, norspermidine rescue. Limitations: Do not turn a bacterial growth result into a human infection-risk estimate. Evidence access: Primary abstract Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22025614/ · DOI 10.1074/jbc.M111.307835
Complete structured claim and evidenceDeleting the carboxypolyamine-decarboxylase orthologue disrupted spermidine synthesis in Campylobacter jejuni.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Bacterial gene deletion and polyamine analysis.
- limitations
- The paper’s microbiome-wide prevalence claim is based on genomic inference; not measured production in each human.
- nutrient_topic
- Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
- plain_language
- Bacteria can use a route different from the human SAM pathway.
- primary_references
- Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22025614/ · DOI 10.1074/jbc.M111.307835
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 414–420
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Bacterial gene deletion and polyamine analysis. · source_derived_draft · unverified_draft
## spermidine-microbial-route Bacteria can use a route different from the human SAM pathway. Deleting the carboxypolyamine-decarboxylase orthologue disrupted spermidine synthesis in Campylobacter jejuni. Model: Bacterial gene deletion and polyamine analysis. Limitations: The paper’s microbiome-wide prevalence claim is based on genomic inference; not measured production in each human. Evidence access: Primary abstract Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22025614/ · DOI 10.1074/jbc.M111.307835
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.