{"id":"d9fde310-ea06-5ca6-ae95-89fbdd2f3a50","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-microbial-growth","predicate":"deletion_impairs","statement":"Polyamine-auxotrophic Campylobacter deletion strains grew poorly; supplied related polyamines could rescue growth.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a7da1273-3533-5b6d-b10a-a591aa989962","mechanism_event_label":"Polyamines can support microbial growth, including a pathogen.","subject":{"id":"1402ca08-4b69-5878-92c8-143115e56fc9","slug":"campylobacter-jejuni-carboxyspermidine-decarboxylase","display_name":"Campylobacter jejuni carboxyspermidine decarboxylase","entity_type_key":"protein"},"object":{"id":"ad7fe199-e12f-5472-847f-0b6aec99c435","slug":"campylobacter-jejuni-growth","display_name":"Campylobacter jejuni growth","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a7da1273-3533-5b6d-b10a-a591aa989962","stable_key":"88eb7407-f147-558b-889b-0c89c4e0aa4a:spermidine-microbial-growth-event","event_type":"observed_relationship","label":"Polyamines can support microbial growth, including a pathogen.","description":"Polyamine-auxotrophic Campylobacter deletion strains grew poorly; supplied related polyamines could rescue growth.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1402ca08-4b69-5878-92c8-143115e56fc9","slug":"campylobacter-jejuni-carboxyspermidine-decarboxylase","display_name":"Campylobacter jejuni carboxyspermidine decarboxylase","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ad7fe199-e12f-5472-847f-0b6aec99c435","slug":"campylobacter-jejuni-growth","display_name":"Campylobacter jejuni growth","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7014993c-468f-5c6b-ab04-80c87f9dfd9f","slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Bacterial culture; homospermidine and, less strongly, norspermidine rescue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not turn a bacterial growth result into a human infection-risk estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"spermidine","display_name":"Spermidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Polyamines can support microbial growth, including a pathogen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22025614/ · DOI 10.1074/jbc.M111.307835","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a1834f83-1d54-5017-bdf6-cdb2e0204731","evidence_kind":"source_excerpt","locator":"Lines 422-428","start_line":422,"end_line":428,"excerpt":"## spermidine-microbial-growth\nPolyamines can support microbial growth, including a pathogen.\nPolyamine-auxotrophic Campylobacter deletion strains grew poorly; supplied related polyamines could rescue growth.\nModel: Bacterial culture; homospermidine and, less strongly, norspermidine rescue.\nLimitations: Do not turn a bacterial growth result into a human infection-risk estimate.\nEvidence access: Primary abstract\nAlternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22025614/ · DOI 10.1074/jbc.M111.307835","model_system":"Bacterial culture; homospermidine and, less strongly, norspermidine rescue.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4348f3f8-0180-58a3-b61c-55d03bb322d2","stable_key":"import-88eb7407-f147-558b-889b-0c89c4e0aa4a","title":"Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"8eec8784bc2bd0384cfd53c6603c4ced8e53c227d9ab29ed85594c43e34c68ef","revision_id":"7c421a18-4526-59f6-b84e-4be533bc35ac","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}