Component
PPAR gamma reporter construct in the 2015 cinnamaldehyde study; construct species unresolved
PPAR gamma reporter construct in the 2015 cinnamaldehyde study; construct species unresolved. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Cinnamaldehyde activated the PPAR gamma reporter in the TSA201 transfection experiment.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ceylon-research/26227398.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea", "start_char": 0, "end_char": 1580, "text_sha256": "6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea"}
- experimental_model
- Transient receptor reporters and 3T3-L1 expression assays
- exposure
- Purified cinnamaldehyde; reporter construct species/isoforms not resolved from abstract
- limitations
- Reporter activation is not proof of direct receptor binding, a particular RXR isoform, vitamin A sparing, or human insulin sensitization.
- nutrient_topic
- Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. · Ceylon cinnamon / Cinnamomum verum bark preparations
- organism
- Human-derived TSA201 host cells; mouse adipocytes
- plain_language
- A receptor-controlled gene reporter increased; the exact binding mechanism remains unresolved.
- primary_references
- [ceylon-p26227398] Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR. (2015). https://pubmed.ncbi.nlm.nih.gov/26227398/ DOI: 10.1142/s0192415x15500512
- tissue_or_cell_type
- Transfected receptor reporter systems
Ceylon cinnamon: metabolism, signaling and nutrient connections (2026-09-17) · lines 675–686
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transient receptor reporters and 3T3-L1 expression assays · source_derived_draft · unverified_draft
### ceylon-pparg Cinnamaldehyde activated the PPAR gamma reporter in the TSA201 transfection experiment. Condition category: normal nutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect. plain_language: A receptor-controlled gene reporter increased; the exact binding mechanism remains unresolved. organism: Human-derived TSA201 host cells; mouse adipocytes tissue_or_cell_type: Transfected receptor reporter systems experimental_model: Transient receptor reporters and 3T3-L1 expression assays limitations: Reporter activation is not proof of direct receptor binding, a particular RXR isoform, vitamin A sparing, or human insulin sensitization. exposure: Purified cinnamaldehyde; reporter construct species/isoforms not resolved from abstract evidence_span: {"source_cache": "artifacts/ceylon-research/26227398.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea", "start_char": 0, "end_char": 1580, "text_sha256": "6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea"} [ceylon-p26227398] Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR. (2015). https://pubmed.ncbi.nlm.nih.gov/26227398/ DOI: 10.1142/s0192415x15500512
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.