{"id":"5a230f48-464b-5a4c-912a-b3da7f3d3e31","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-pparg","predicate":"activates_reporter","statement":"Cinnamaldehyde activated the PPAR gamma reporter in the TSA201 transfection experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"03ea3232-9e98-5e6e-9683-f59919a95eb7","mechanism_event_label":"A receptor-controlled gene reporter increased; the exact binding mechanism remains unresolved.","subject":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"object":{"id":"559f96e5-fcac-5aea-b975-6754e711416c","slug":"ca-pparg-reporter","display_name":"PPAR gamma reporter construct in the 2015 cinnamaldehyde study; construct species unresolved","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"03ea3232-9e98-5e6e-9683-f59919a95eb7","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-pparg-event","event_type":"biochemical_relationship","label":"A receptor-controlled gene reporter increased; the exact binding mechanism remains unresolved.","description":"Cinnamaldehyde activated the PPAR gamma reporter in the TSA201 transfection experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"559f96e5-fcac-5aea-b975-6754e711416c","slug":"ca-pparg-reporter","display_name":"PPAR gamma reporter construct in the 2015 cinnamaldehyde study; construct species unresolved","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/26227398.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea\", \"start_char\": 0, \"end_char\": 1580, \"text_sha256\": \"6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Transient receptor reporters and 3T3-L1 expression assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Purified cinnamaldehyde; reporter construct species/isoforms not resolved from abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reporter activation is not proof of direct receptor binding, a particular RXR isoform, vitamin A sparing, or human insulin sensitization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human-derived TSA201 host cells; mouse adipocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A receptor-controlled gene reporter increased; the exact binding mechanism remains unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p26227398] Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR. (2015). https://pubmed.ncbi.nlm.nih.gov/26227398/ DOI: 10.1142/s0192415x15500512","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Transfected receptor reporter systems","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"44c4b86a-eacc-5a8b-927c-858ea335ed7c","evidence_kind":"source_excerpt","locator":"Lines 675-686","start_line":675,"end_line":686,"excerpt":"### ceylon-pparg\nCinnamaldehyde activated the PPAR gamma reporter in the TSA201 transfection experiment.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A receptor-controlled gene reporter increased; the exact binding mechanism remains unresolved.\norganism: Human-derived TSA201 host cells; mouse adipocytes\ntissue_or_cell_type: Transfected receptor reporter systems\nexperimental_model: Transient receptor reporters and 3T3-L1 expression assays\nlimitations: Reporter activation is not proof of direct receptor binding, a particular RXR isoform, vitamin A sparing, or human insulin sensitization.\nexposure: Purified cinnamaldehyde; reporter construct species/isoforms not resolved from abstract\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/26227398.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea\", \"start_char\": 0, \"end_char\": 1580, \"text_sha256\": \"6aa67e691d29bd1e0a13dd5e433b9b7aa2265ed650a21acfd66b79c715b7c9ea\"}\n[ceylon-p26227398] Cinnamaldehyde Contributes to Insulin Sensitivity by Activating PPARδ, PPARγ, and RXR. 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