Component

Clostridium sporogenes FldC

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Gnotobiotic mice colonized with the fldC-mutant strain had reduced gut and circulating indolepropionate and increased intestinal permeability compared with wild-type colonization.

    Clostridium sporogenes FldC → Mouse intestinal permeability in microbial tryptophan experiments source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text, host colonization results
    experimental_model
    Gnotobiotic mouse colonization.
    limitations
    Several metabolites changed; this comparison alone does not prove indolepropionate is the sole mediator.
    nutrient_topic
    Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
    plain_language
    A microbial genetic change altered a host barrier phenotype.
    primary_references
    A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29168502/ · DOI 10.1038/nature24661

    Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 514–520

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Gnotobiotic mouse colonization. · source_derived_draft · unverified_draft

    ## tryptophan-fldc-host-effect A microbial genetic change altered a host barrier phenotype. Gnotobiotic mice colonized with the fldC-mutant strain had reduced gut and circulating indolepropionate and increased intestinal permeability compared with wild-type colonization. Model: Gnotobiotic mouse colonization. Limitations: Several metabolites changed; this comparison alone does not prove indolepropionate is the sole mediator. Evidence access: Primary full text, host colonization results A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29168502/ · DOI 10.1038/nature24661
    Complete structured claim and evidence

  2. Disrupting fldC in C. sporogenes abolished indolepropionate accumulation in culture and altered aromatic-amino-acid metabolism.

    Clostridium sporogenes FldC → Indole-3-propionic acid / indolepropionate source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text, Figures 1–3
    experimental_model
    C. sporogenes ClosTron mutant and LC–MS/MS.
    limitations
    The mutation affects phenylalanine and tyrosine products as well; effects cannot all be assigned to indolepropionate.
    nutrient_topic
    Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Tryptophan
    plain_language
    A missing microbial enzyme stopped production despite available tryptophan.
    primary_references
    A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29168502/ · DOI 10.1038/nature24661
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19) · lines 490–496

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · C. sporogenes ClosTron mutant and LC–MS/MS. · source_derived_draft · unverified_draft

    ## tryptophan-fldc-loss A missing microbial enzyme stopped production despite available tryptophan. Disrupting fldC in C. sporogenes abolished indolepropionate accumulation in culture and altered aromatic-amino-acid metabolism. Model: C. sporogenes ClosTron mutant and LC–MS/MS. Limitations: The mutation affects phenylalanine and tyrosine products as well; effects cannot all be assigned to indolepropionate. Evidence access: Primary full text, Figures 1–3 A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. · 2017 · https://pubmed.ncbi.nlm.nih.gov/29168502/ · DOI 10.1038/nature24661
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards