Component
p21 and p27 abundance in experimental bronchial cells
p21 and p27 abundance in experimental bronchial cells. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The metabolite increased p21 and p27 protein in the tested bronchial cells.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/lycopene-research/17420169.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84a4b4088d833621e68106129dcbe8ddda9e743ec613cebdd4ce9cf03daeb15c", "start_char": 0, "end_char": 1675, "text_sha256": "84a4b4088d833621e68106129dcbe8ddda9e743ec613cebdd4ce9cf03daeb15c"}
- experimental_model
- Cell-cycle assays and NNK-induced mouse tumor model
- exposure
- Apo-10-prime-lycopenoic acid; mouse diets 10, 40 or 120 mg/kg
- limitations
- Metabolite exposure, not a clinical lycopene trial; tumor multiplicity is not human survival.
- nutrient_topic
- Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
- organism
- Human bronchial cell lines; A/J mice separately specified
- plain_language
- Proteins that restrain cell-cycle progression increased.
- primary_references
- [lycopene-p17420169] Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. (2007). https://pubmed.ncbi.nlm.nih.gov/17420169/ DOI: 10.1093/carcin/bgm076
- tissue_or_cell_type
- Bronchial epithelium and lung tumors
Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 728–739
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cell-cycle assays and NNK-induced mouse tumor model · source_derived_draft · unverified_draft
### lycopene-apo-p21-p27 The metabolite increased p21 and p27 protein in the tested bronchial cells. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Proteins that restrain cell-cycle progression increased. organism: Human bronchial cell lines; A/J mice separately specified tissue_or_cell_type: Bronchial epithelium and lung tumors experimental_model: Cell-cycle assays and NNK-induced mouse tumor model limitations: Metabolite exposure, not a clinical lycopene trial; tumor multiplicity is not human survival. exposure: Apo-10-prime-lycopenoic acid; mouse diets 10, 40 or 120 mg/kg evidence_span: {"source_cache": "artifacts/lycopene-research/17420169.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84a4b4088d833621e68106129dcbe8ddda9e743ec613cebdd4ce9cf03daeb15c", "start_char": 0, "end_char": 1675, "text_sha256": "84a4b4088d833621e68106129dcbe8ddda9e743ec613cebdd4ce9cf03daeb15c"} [lycopene-p17420169] Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. (2007). https://pubmed.ncbi.nlm.nih.gov/17420169/ DOI: 10.1093/carcin/bgm076
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.