Component
Breast-milk iodine concentration
Breast-milk iodine concentration. Study-specific scope and measurement methods are recorded with each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Breast-milk iodine concentration was higher with maternal supplementation than with direct infant supplementation over follow-up (P<0.0001).
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary PDF Methods, trial profile, Results and Table2, pp.197–209.
- experimental_model
- Double-blind randomized trial in Morocco;241 mother–infant pairs enrolled, 239 randomized after two age exclusions
- exposure
- Term infants ≤ 8 weeks; indirect arm 121 pairs: mother 400 mg iodine as oral iodized poppyseed oil, infant placebo; direct arm 118 pairs: infant about 100 mg iodine from half a 200 mg oil capsule, mother placebo; follow-up 3, 6, 9 months.
- limitations
- Both arms received active iodine somewhere in the pair; there was no wholly untreated arm. Breastfeeding and baseline deficiency contextualize the result; measured iodine status is not a child cognitive outcome. Actual infant study dose was about 100 mg, not the 200 mg guideline discussed elsewhere in the paper.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- Treating the mother increased the iodine delivered in her milk in this deficient setting.
- primary_references
- [iod-clin-bouhouch2014] Direct iodine supplementation of infants versus supplementation of their breastfeeding mothers: a double-blind, randomised, placebo-controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24622750/ DOI: 10.1016/s2213-8587(13)70155-4
- tissue_or_cell_type
- Breast milk, infant urine and thyroid function
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1538–1550
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized trial in Morocco;241 mother–infant pairs enrolled, 239 randomized after two age exclusions · source_derived_draft · unverified_draft
### iod-clin-lactation-milk Breast-milk iodine concentration was higher with maternal supplementation than with direct infant supplementation over follow-up (P<0.0001). Condition category: nutrient_deficiency nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Treating the mother increased the iodine delivered in her milk in this deficient setting. organism: Homo sapiens tissue_or_cell_type: Breast milk, infant urine and thyroid function experimental_model: Double-blind randomized trial in Morocco;241 mother–infant pairs enrolled, 239 randomized after two age exclusions limitations: Both arms received active iodine somewhere in the pair; there was no wholly untreated arm. Breastfeeding and baseline deficiency contextualize the result; measured iodine status is not a child cognitive outcome. Actual infant study dose was about 100 mg, not the 200 mg guideline discussed elsewhere in the paper. exposure: Term infants ≤ 8 weeks; indirect arm 121 pairs: mother 400 mg iodine as oral iodized poppyseed oil, infant placebo; direct arm 118 pairs: infant about 100 mg iodine from half a 200 mg oil capsule, mother placebo; follow-up 3, 6, 9 months. cross_nutrient: false evidence_location: Primary PDF Methods, trial profile, Results and Table2, pp.197–209. [iod-clin-bouhouch2014] Direct iodine supplementation of infants versus supplementation of their breastfeeding mothers: a double-blind, randomised, placebo-controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24622750/ DOI: 10.1016/s2213-8587(13)70155-4
Complete structured claim and evidence
Where it participates (unsigned role)
Infant urinary iodine was higher in the maternal-supplement arm (P=0.042); group medians exceeded 100 micrograms/L at 3 and 6 months in that arm, versus only 6 months in the direct-infant arm.
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary PDF Methods, trial profile, Results and Table2, pp.197–209.
- experimental_model
- Double-blind randomized trial in Morocco;241 mother–infant pairs enrolled, 239 randomized after two age exclusions
- exposure
- Term infants ≤ 8 weeks; indirect arm 121 pairs: mother 400 mg iodine as oral iodized poppyseed oil, infant placebo; direct arm 118 pairs: infant about 100 mg iodine from half a 200 mg oil capsule, mother placebo; follow-up 3, 6, 9 months.
- limitations
- Both arms received active iodine somewhere in the pair; there was no wholly untreated arm. Breastfeeding and baseline deficiency contextualize the result; measured iodine status is not a child cognitive outcome. Actual infant study dose was about 100 mg, not the 200 mg guideline discussed elsewhere in the paper. The 100-microgram/L statement concerns group medians as interpreted by the paper, not proof of adequacy in every infant.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- The maternal route improved the infants’ measured iodine status for longer.
- primary_references
- [iod-clin-bouhouch2014] Direct iodine supplementation of infants versus supplementation of their breastfeeding mothers: a double-blind, randomised, placebo-controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24622750/ DOI: 10.1016/s2213-8587(13)70155-4
- tissue_or_cell_type
- Breast milk, infant urine and thyroid function
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1552–1564
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized trial in Morocco;241 mother–infant pairs enrolled, 239 randomized after two age exclusions · source_derived_draft · unverified_draft
### iod-clin-lactation-infant-urine Infant urinary iodine was higher in the maternal-supplement arm (P=0.042); group medians exceeded 100 micrograms/L at 3 and 6 months in that arm, versus only 6 months in the direct-infant arm. Condition category: nutrient_deficiency nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: The maternal route improved the infants’ measured iodine status for longer. organism: Homo sapiens tissue_or_cell_type: Breast milk, infant urine and thyroid function experimental_model: Double-blind randomized trial in Morocco;241 mother–infant pairs enrolled, 239 randomized after two age exclusions limitations: Both arms received active iodine somewhere in the pair; there was no wholly untreated arm. Breastfeeding and baseline deficiency contextualize the result; measured iodine status is not a child cognitive outcome. Actual infant study dose was about 100 mg, not the 200 mg guideline discussed elsewhere in the paper. The 100-microgram/L statement concerns group medians as interpreted by the paper, not proof of adequacy in every infant. exposure: Term infants ≤ 8 weeks; indirect arm 121 pairs: mother 400 mg iodine as oral iodized poppyseed oil, infant placebo; direct arm 118 pairs: infant about 100 mg iodine from half a 200 mg oil capsule, mother placebo; follow-up 3, 6, 9 months. cross_nutrient: false evidence_location: Primary PDF Methods, trial profile, Results and Table2, pp.197–209. [iod-clin-bouhouch2014] Direct iodine supplementation of infants versus supplementation of their breastfeeding mothers: a double-blind, randomised, placebo-controlled trial. (2014). https://pubmed.ncbi.nlm.nih.gov/24622750/ DOI: 10.1016/s2213-8587(13)70155-4
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.