Component
Brain lipid peroxidation after carbon monoxide poisoning
Brain lipid peroxidation after carbon monoxide poisoning. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Exposing rats to 3 ATA pressure with 0.21 ATA oxygen after poisoning had no significant effects, and 1 ATA oxygen did not significantly inhibit xanthine oxidase formation or lipid peroxidation.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/hbot-research/8248932.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f", "start_char": 0, "end_char": 1870, "text_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f"}
- experimental_model
- Rats poisoned with carbon monoxide, with leukocyte function assays
- exposure
- 3 atmospheres absolute for 45 minutes, given 24 hours before or up to 45 minutes after poisoning; 3 ATA pressure without oxygen as a control
- limitations
- The pressure-only control separates oxygen from pressure. The integrin defect is functional: surface expression was normal, which is the informative detail.
- nutrient_topic
- Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
- organism
- Rat
- plain_language
- Pressure by itself did nothing; it is the oxygen at pressure that matters.
- primary_references
- [hbot-p8248932] Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8248932/ DOI: 10.1006/taap.1993.1243
- tissue_or_cell_type
- Brain microvasculature and polymorphonuclear leukocytes
Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 777–788
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rats poisoned with carbon monoxide, with leukocyte function assays · source_derived_draft · unverified_draft
### hbot-pressure-alone-ineffective Exposing rats to 3 ATA pressure with 0.21 ATA oxygen after poisoning had no significant effects, and 1 ATA oxygen did not significantly inhibit xanthine oxidase formation or lipid peroxidation. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Pressure by itself did nothing; it is the oxygen at pressure that matters. organism: Rat tissue_or_cell_type: Brain microvasculature and polymorphonuclear leukocytes experimental_model: Rats poisoned with carbon monoxide, with leukocyte function assays limitations: The pressure-only control separates oxygen from pressure. The integrin defect is functional: surface expression was normal, which is the informative detail. exposure: 3 atmospheres absolute for 45 minutes, given 24 hours before or up to 45 minutes after poisoning; 3 ATA pressure without oxygen as a control evidence_span: {"source_cache": "artifacts/hbot-research/8248932.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f", "start_char": 0, "end_char": 1870, "text_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f"} [hbot-p8248932] Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8248932/ DOI: 10.1006/taap.1993.1243
Complete structured claim and evidence
Where it participates (unsigned role)
Exposure inhibited carbon monoxide-mediated brain lipid peroxidation by preventing the conversion of xanthine dehydrogenase to oxidase, a conversion known to be due to the action of leukocytes.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/hbot-research/8248932.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f", "start_char": 0, "end_char": 1870, "text_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f"}
- experimental_model
- Rats poisoned with carbon monoxide, with leukocyte function assays
- exposure
- 3 atmospheres absolute for 45 minutes, given 24 hours before or up to 45 minutes after poisoning; 3 ATA pressure without oxygen as a control
- limitations
- The pressure-only control separates oxygen from pressure. The integrin defect is functional: surface expression was normal, which is the informative detail.
- nutrient_topic
- Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. · Hyperbaric oxygen therapy
- organism
- Rat
- plain_language
- Stopping the white cells sticking stops the enzyme switch that generates the damage.
- primary_references
- [hbot-p8248932] Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8248932/ DOI: 10.1006/taap.1993.1243
- tissue_or_cell_type
- Brain microvasculature and polymorphonuclear leukocytes
Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19) · lines 764–775
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rats poisoned with carbon monoxide, with leukocyte function assays · source_derived_draft · unverified_draft
### hbot-xanthine-oxidase-prevention Exposure inhibited carbon monoxide-mediated brain lipid peroxidation by preventing the conversion of xanthine dehydrogenase to oxidase, a conversion known to be due to the action of leukocytes. Condition category: normal nutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake. plain_language: Stopping the white cells sticking stops the enzyme switch that generates the damage. organism: Rat tissue_or_cell_type: Brain microvasculature and polymorphonuclear leukocytes experimental_model: Rats poisoned with carbon monoxide, with leukocyte function assays limitations: The pressure-only control separates oxygen from pressure. The integrin defect is functional: surface expression was normal, which is the informative detail. exposure: 3 atmospheres absolute for 45 minutes, given 24 hours before or up to 45 minutes after poisoning; 3 ATA pressure without oxygen as a control evidence_span: {"source_cache": "artifacts/hbot-research/8248932.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f", "start_char": 0, "end_char": 1870, "text_sha256": "54ab057eb31320490d893896d8ab5b0c856a8b59489424b14b81409f01a78f7f"} [hbot-p8248932] Functional inhibition of leukocyte B2 integrins by hyperbaric oxygen in carbon monoxide-mediated brain injury in rats. (1993). https://pubmed.ncbi.nlm.nih.gov/8248932/ DOI: 10.1006/taap.1993.1243
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
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Open hypotheses
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This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.