Component
Bovine endothelial nitric oxide synthase / NOS3
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
SAC increased eNOS phosphorylation in BAE-1 cells.
Experimental context and source evidence
- acting_entity
- s-allylcysteine
- dose
- Not specified in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary abstract
- experimental_comparison
- Purified SAC and black garlic extract tested separately
- experimental_model
- Bovine aortic endothelial BAE-1 cells
- interpretation_status
- Source-derived research curation; not independent primary verification
- limitations
- Bovine cell result; phosphorylation site and human clinical effect not established by the accessed abstract.
- nutrient_topic
- S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · S-allyl-L-cysteine / SAC
- organism
- Bos taurus
- plain_language
- A nitric-oxide-producing enzyme connects sulfur signaling to vascular biology.
- primary_references
- [37062967] Improving endothelial health with food-derived H2S donors: an in vitro study with S-allyl cysteine and with a black-garlic extract enriched in sulfur-containing compounds. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37062967/ · DOI 10.1039/d3fo00412k
- route
- Cell culture
- tissue_or_cell_type
- Bovine aortic endothelial BAE-1 cells
S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20) · lines 275–282
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Bovine aortic endothelial BAE-1 cells · source_derived_draft · unverified_draft
## s-allylcysteine-bovine-enos A nitric-oxide-producing enzyme connects sulfur signaling to vascular biology. SAC increased eNOS phosphorylation in BAE-1 cells. Model: Bovine aortic endothelial BAE-1 cells Limitations: Bovine cell result; phosphorylation site and human clinical effect not established by the accessed abstract. Evidence access: Primary abstract [37062967] Improving endothelial health with food-derived H2S donors: an in vitro study with S-allyl cysteine and with a black-garlic extract enriched in sulfur-containing compounds. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37062967/ · DOI 10.1039/d3fo00412k Structured context: {"organism": "Bos taurus", "tissue_or_cell_type": "Bovine aortic endothelial BAE-1 cells", "dose": "Not specified in accessed abstract", "duration": "Not specified in accessed abstract", "route": "Cell culture", "experimental_comparison": "Purified SAC and black garlic extract tested separately", "acting_entity": "s-allylcysteine", "interpretation_status": "Source-derived research curation; not independent primary verification"}
Complete structured claim and evidence
Where it participates (unsigned role)
SAC increased the NO-release readout in BAE-1 cells.
Experimental context and source evidence
- acting_entity
- s-allylcysteine
- dose
- Not specified in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary abstract
- experimental_comparison
- Purified SAC and black garlic extract tested separately
- experimental_model
- Bovine aortic endothelial BAE-1 cells
- interpretation_status
- Source-derived research curation; not independent primary verification
- limitations
- Not proof of lowered human blood pressure or independence from arginine and NOS cofactors.
- nutrient_topic
- S-allylcysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · S-allyl-L-cysteine / SAC
- organism
- Bos taurus
- plain_language
- The downstream gas signal was measured separately.
- primary_references
- [37062967] Improving endothelial health with food-derived H2S donors: an in vitro study with S-allyl cysteine and with a black-garlic extract enriched in sulfur-containing compounds. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37062967/ · DOI 10.1039/d3fo00412k
- route
- Cell culture
- tissue_or_cell_type
- Bovine aortic endothelial BAE-1 cells
S-allylcysteine: sulfur signaling, redox responses and cross-nutrient mechanisms (2026-09-20) · lines 284–291
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Bovine aortic endothelial BAE-1 cells · source_derived_draft · unverified_draft
## s-allylcysteine-bovine-no The downstream gas signal was measured separately. SAC increased the NO-release readout in BAE-1 cells. Model: Bovine aortic endothelial BAE-1 cells Limitations: Not proof of lowered human blood pressure or independence from arginine and NOS cofactors. Evidence access: Primary abstract [37062967] Improving endothelial health with food-derived H2S donors: an in vitro study with S-allyl cysteine and with a black-garlic extract enriched in sulfur-containing compounds. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37062967/ · DOI 10.1039/d3fo00412k Structured context: {"organism": "Bos taurus", "tissue_or_cell_type": "Bovine aortic endothelial BAE-1 cells", "dose": "Not specified in accessed abstract", "duration": "Not specified in accessed abstract", "route": "Cell culture", "experimental_comparison": "Purified SAC and black garlic extract tested separately", "acting_entity": "s-allylcysteine", "interpretation_status": "Source-derived research curation; not independent primary verification"}
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.