Component
Placebo-adjusted whole-blood transcriptome contrast
Study-defined Placebo-adjusted whole-blood transcriptome contrast. Read each linked record for species, exposure and endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Difference-in-difference testing found no significant probe changes in the white-European cohort or pooled D2/D3-versus-placebo analyses; five were found specifically for D3 versus placebo in the South-Asian cohort, largely driven by placebo-group changes.
Experimental context and source evidence
- cross_nutrient
- false
- experimental_model
- 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women
- exposure
- 15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end.
- limitations
- Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint.
- nutrient_topic
- Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin D2 and D3
- organism
- Homo sapiens
- plain_language
- The strongest direct comparisons were much less conclusive than the within-group gene-change lists.
- primary_references
- [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
- tissue_or_cell_type
- Whole blood
Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1087–1098
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women · source_derived_draft · unverified_draft
### vd-durrant-direct-contrast Difference-in-difference testing found no significant probe changes in the white-European cohort or pooled D2/D3-versus-placebo analyses; five were found specifically for D3 versus placebo in the South-Asian cohort, largely driven by placebo-group changes. Condition category: normal nutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The strongest direct comparisons were much less conclusive than the within-group gene-change lists. organism: Homo sapiens tissue_or_cell_type: Whole blood experimental_model: 97 participant transcriptomic subset of Tripkovic 2017; 67 white-European and 30 South-Asian women limitations: Exploratory selected trial subset; differences in baseline status, season and whole-blood cell composition may matter. Within-group significance is not a significant difference between groups; no infection endpoint. exposure: 15 micrograms/day D2 or D3 or placebo for 12 winter weeks; blood microarrays at baseline/end. cross_nutrient: false [durrant2022] Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome. (2022). https://pubmed.ncbi.nlm.nih.gov/35281034/ DOI: 10.3389/fimmu.2022.790444
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.