Component
Beta-hydroxybutyric acid
Ketone acid used as a racemic acid infusion in the cited experiment; distinct from its measured anion.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention.
Experimental context and source evidence
- endpoint
- Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention.
- experimental-exposure
- Acute ketone-acid infusion with intact endocrine pancreas; redistribution-associated hypokalemia, not nutritional potassium depletion.
- experimental_model
- Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.
- limitations
- Redistribution is supported by renal-excretion controls; hepatic uptake and hormonal causation were proposed, not definitively localized. Other organic acids were untested.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Canis lupus familiaris
- plain_language
- Acidemia alone did not predict the direction of blood potassium change.
- primary_references
- [adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775
- tissue_or_cell_type
- systemic circulation
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1177–1188
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies. · source_derived_draft · unverified_draft
### ketoacid-infusion-lowers-plasma-k Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Acidemia alone did not predict the direction of blood potassium change. organism: Canis lupus familiaris tissue_or_cell_type: systemic circulation experimental_model: Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies. limitations: Redistribution is supported by renal-excretion controls; hepatic uptake and hormonal causation were proposed, not definitively localized. Other organic acids were untested. experimental-exposure: Acute ketone-acid infusion with intact endocrine pancreas; redistribution-associated hypokalemia, not nutritional potassium depletion. endpoint: Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention. [adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775
Complete structured claim and evidenceBeta-hydroxybutyric acid infusion increased portal insulin in conscious dogs.
Experimental context and source evidence
- endpoint
- Beta-hydroxybutyric acid infusion increased portal insulin in conscious dogs.
- experimental-exposure
- Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.
- experimental_model
- Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.
- limitations
- Racemic ketone-acid infusion into nondiabetic animals does not model insulin-deficient diabetic ketoacidosis.
- nutrient_topic
- Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
- organism
- Canis lupus familiaris
- plain_language
- The ketone-acid intervention changed the hormone environment that controls potassium distribution.
- primary_references
- [adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775
- tissue_or_cell_type
- pancreatic-portal circulation
Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1164–1175
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies. · source_derived_draft · unverified_draft
### ketoacid-infusion-raises-portal-insulin Beta-hydroxybutyric acid infusion increased portal insulin in conscious dogs. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The ketone-acid intervention changed the hormone environment that controls potassium distribution. organism: Canis lupus familiaris tissue_or_cell_type: pancreatic-portal circulation experimental_model: Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies. limitations: Racemic ketone-acid infusion into nondiabetic animals does not model insulin-deficient diabetic ketoacidosis. experimental-exposure: Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies. endpoint: Beta-hydroxybutyric acid infusion increased portal insulin in conscious dogs. [adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775
Complete structured claim and evidence
Where it participates (unsigned role)
Serum beta-hydroxybutyrate increased compared with placebo.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/25989216.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539", "start_char": 0, "end_char": 1522, "text_sha256": "2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539"}
- experimental_model
- Double-blind randomized placebo-controlled trial
- exposure
- Mangiferin 150 mg/day for 12 weeks
- limitations
- One trial in a selected population; biomarkers do not demonstrate clinical outcomes or directly measure fatty-acid flux.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Overweight adults with hyperlipidemia; 97 completers
- plain_language
- A circulating ketone measure increased.
- primary_references
- [mangiferin-p25989216] Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25989216/ DOI: 10.1038/srep10344
- tissue_or_cell_type
- Serum metabolic measurements
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1212–1223
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind randomized placebo-controlled trial · source_derived_draft · unverified_draft
### mangiferin-trial-bhb Serum beta-hydroxybutyrate increased compared with placebo. Condition category: normal nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: A circulating ketone measure increased. organism: Overweight adults with hyperlipidemia; 97 completers tissue_or_cell_type: Serum metabolic measurements experimental_model: Double-blind randomized placebo-controlled trial limitations: One trial in a selected population; biomarkers do not demonstrate clinical outcomes or directly measure fatty-acid flux. exposure: Mangiferin 150 mg/day for 12 weeks evidence_span: {"source_cache": "artifacts/mangiferin-research/25989216.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539", "start_char": 0, "end_char": 1522, "text_sha256": "2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539"} [mangiferin-p25989216] Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25989216/ DOI: 10.1038/srep10344
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.