{"id":"aff2b179-3d40-53db-bf09-7fdc53ecf6ae","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:ketoacid-infusion-lowers-plasma-k","predicate":"infusion-decreases","statement":"Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"639c6217-8f5a-576c-ba82-e1df3600b783","mechanism_event_label":"Acidemia alone did not predict the direction of blood potassium change.","subject":{"id":"04944c93-c08b-5313-b0ce-1f3d8fa33220","slug":"beta-hydroxybutyric-acid","display_name":"Beta-hydroxybutyric acid","entity_type_key":"small_molecule"},"object":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"639c6217-8f5a-576c-ba82-e1df3600b783","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:ketoacid-infusion-lowers-plasma-k-event","event_type":"biochemical_relationship","label":"Acidemia alone did not predict the direction of blood potassium change.","description":"Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"04944c93-c08b-5313-b0ce-1f3d8fa33220","slug":"beta-hydroxybutyric-acid","display_name":"Beta-hydroxybutyric acid","entity_type_key":"small_molecule"},"role":"upstream","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"91de6063-d0ae-5f4c-9935-75bcec18c7b5","slug":"serum-potassium-concentration","display_name":"Serum or plasma potassium concentration","entity_type_key":"cellular_process"},"role":"downstream","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"associated-hormonal-response","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"endpoint","value_text":"Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental-exposure","value_text":"Acute ketone-acid infusion with intact endocrine pancreas; redistribution-associated hypokalemia, not nutritional potassium depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Redistribution is supported by renal-excretion controls; hepatic uptake and hormonal causation were proposed, not definitively localized. Other organic acids were untested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Canis lupus familiaris","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Acidemia alone did not predict the direction of blood potassium change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"systemic circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"91d51a60-fb78-5732-8cab-9b2890576885","evidence_kind":"source_excerpt","locator":"Lines 1177-1188","start_line":1177,"end_line":1188,"excerpt":"### ketoacid-infusion-lowers-plasma-k\nBeta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Acidemia alone did not predict the direction of blood potassium change.\norganism: Canis lupus familiaris\ntissue_or_cell_type: systemic circulation\nexperimental_model: Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.\nlimitations: Redistribution is supported by renal-excretion controls; hepatic uptake and hormonal causation were proposed, not definitively localized. Other organic acids were untested.\nexperimental-exposure: Acute ketone-acid infusion with intact endocrine pancreas; redistribution-associated hypokalemia, not nutritional potassium depletion.\nendpoint: Beta-hydroxybutyric acid infusion lowered plasma potassium despite acidemia comparable to the HCl intervention.\n[adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775","model_system":"Twelve conscious dogs with portal/hepatic/systemic sampling; beta-hydroxybutyric acid 7 mEq/kg or HCl 3 mEq/kg infused over 30 minutes; additional anesthetized and obstructed-urinary-tract studies.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [adrogue-1985-acid-infusion] Role of the endocrine pancreas in the kalemic response to acute metabolic acidosis in conscious dogs (1985). https://www.jci.org/articles/view/111775 DOI: 10.1172/JCI111775","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}