Component

ARV1 (human ER membrane protein)

ARV1 (human ER membrane protein). Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. ARV1-containing GPI-GnT used PI more efficiently than the ARV1-less complex in vitro.

    ARV1 (human ER membrane protein) → Human GPI N-acetylglucosaminyltransferase complex source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/40378954.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917", "start_char": 0, "end_char": 1260, "text_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917"}
    experimental_model
    Human-cell gene perturbation and isolated-complex activity
    exposure
    ARV1/PIGQ association and PI utilization
    limitations
    The ring-shaped assembly was AlphaFold-predicted, not an experimentally resolved structure. Effects on GPI-anchored proteins varied by cell and protein.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Homo sapiens
    plain_language
    The anchor pathway depends on substrate handling, not only the total amount of inositol.
    primary_references
    [ino-p40378954] ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis. (2025). https://pubmed.ncbi.nlm.nih.gov/40378954/ DOI: 10.1016/j.jbc.2025.110236
    tissue_or_cell_type
    Fibroblasts, HEK293 cells and ER enzyme complex

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1146–1157

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human-cell gene perturbation and isolated-complex activity · source_derived_draft · unverified_draft

    ### ino-arv1-pi ARV1-containing GPI-GnT used PI more efficiently than the ARV1-less complex in vitro. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: The anchor pathway depends on substrate handling, not only the total amount of inositol. organism: Homo sapiens tissue_or_cell_type: Fibroblasts, HEK293 cells and ER enzyme complex experimental_model: Human-cell gene perturbation and isolated-complex activity limitations: The ring-shaped assembly was AlphaFold-predicted, not an experimentally resolved structure. Effects on GPI-anchored proteins varied by cell and protein. exposure: ARV1/PIGQ association and PI utilization evidence_span: {"source_cache": "artifacts/inositol-research/40378954.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917", "start_char": 0, "end_char": 1260, "text_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917"} [ino-p40378954] ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis. (2025). https://pubmed.ncbi.nlm.nih.gov/40378954/ DOI: 10.1016/j.jbc.2025.110236
    Complete structured claim and evidence

  2. Human ARV1 associated with PIGQ; disrupting that association removed ARV1-mediated enhancement of GPI-GnT activity.

    ARV1 (human ER membrane protein) → PIGQ (human GPI biosynthesis subunit) source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/inositol-research/40378954.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917", "start_char": 0, "end_char": 1260, "text_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917"}
    experimental_model
    Human-cell gene perturbation and isolated-complex activity
    exposure
    ARV1/PIGQ association and PI utilization
    limitations
    The ring-shaped assembly was AlphaFold-predicted, not an experimentally resolved structure. Effects on GPI-anchored proteins varied by cell and protein.
    nutrient_topic
    Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
    organism
    Homo sapiens
    plain_language
    A partner protein helps the anchor-building enzyme work efficiently.
    primary_references
    [ino-p40378954] ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis. (2025). https://pubmed.ncbi.nlm.nih.gov/40378954/ DOI: 10.1016/j.jbc.2025.110236
    tissue_or_cell_type
    Fibroblasts, HEK293 cells and ER enzyme complex

    Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1133–1144

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human-cell gene perturbation and isolated-complex activity · source_derived_draft · unverified_draft

    ### ino-arv1-pigq Human ARV1 associated with PIGQ; disrupting that association removed ARV1-mediated enhancement of GPI-GnT activity. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: A partner protein helps the anchor-building enzyme work efficiently. organism: Homo sapiens tissue_or_cell_type: Fibroblasts, HEK293 cells and ER enzyme complex experimental_model: Human-cell gene perturbation and isolated-complex activity limitations: The ring-shaped assembly was AlphaFold-predicted, not an experimentally resolved structure. Effects on GPI-anchored proteins varied by cell and protein. exposure: ARV1/PIGQ association and PI utilization evidence_span: {"source_cache": "artifacts/inositol-research/40378954.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917", "start_char": 0, "end_char": 1260, "text_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917"} [ino-p40378954] ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis. (2025). https://pubmed.ncbi.nlm.nih.gov/40378954/ DOI: 10.1016/j.jbc.2025.110236
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards