Component
PIGQ (human GPI biosynthesis subunit)
PIGQ (human GPI biosynthesis subunit). Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Human ARV1 associated with PIGQ; disrupting that association removed ARV1-mediated enhancement of GPI-GnT activity.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/inositol-research/40378954.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917", "start_char": 0, "end_char": 1260, "text_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917"}
- experimental_model
- Human-cell gene perturbation and isolated-complex activity
- exposure
- ARV1/PIGQ association and PI utilization
- limitations
- The ring-shaped assembly was AlphaFold-predicted, not an experimentally resolved structure. Effects on GPI-anchored proteins varied by cell and protein.
- nutrient_topic
- Inositol research collection; topical membership is not evidence of a direct dietary effect. · Inositol (stereoisomer family)
- organism
- Homo sapiens
- plain_language
- A partner protein helps the anchor-building enzyme work efficiently.
- primary_references
- [ino-p40378954] ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis. (2025). https://pubmed.ncbi.nlm.nih.gov/40378954/ DOI: 10.1016/j.jbc.2025.110236
- tissue_or_cell_type
- Fibroblasts, HEK293 cells and ER enzyme complex
Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17) · lines 1133–1144
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human-cell gene perturbation and isolated-complex activity · source_derived_draft · unverified_draft
### ino-arv1-pigq Human ARV1 associated with PIGQ; disrupting that association removed ARV1-mediated enhancement of GPI-GnT activity. Condition category: normal nutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect. plain_language: A partner protein helps the anchor-building enzyme work efficiently. organism: Homo sapiens tissue_or_cell_type: Fibroblasts, HEK293 cells and ER enzyme complex experimental_model: Human-cell gene perturbation and isolated-complex activity limitations: The ring-shaped assembly was AlphaFold-predicted, not an experimentally resolved structure. Effects on GPI-anchored proteins varied by cell and protein. exposure: ARV1/PIGQ association and PI utilization evidence_span: {"source_cache": "artifacts/inositol-research/40378954.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917", "start_char": 0, "end_char": 1260, "text_sha256": "858f4bd2342d09239e21945d3d83aab06d84f33da26cb788e3ac091b713a1917"} [ino-p40378954] ARV1 is a component of the enzyme initiating glycosylphosphatidylinositol biosynthesis. (2025). https://pubmed.ncbi.nlm.nih.gov/40378954/ DOI: 10.1016/j.jbc.2025.110236
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.