Component

Antioxidant response element reporter transcription

Antioxidant response element reporter transcription. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Lycopene treatment increased ARE-driven reporter expression in transfected cancer cells.

    Lycopene → Antioxidant response element reporter transcription source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/15657364.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32", "start_char": 0, "end_char": 1890, "text_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32"}
    experimental_model
    Reporter, expression and dominant-negative transcription-factor experiments
    exposure
    Lycopene and ethanolic derivative extract
    limitations
    Unidentified derivative extract was active; direct binding of intact lycopene to KEAP1 was not established.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Human cancer cell cultures
    plain_language
    Cells activated a protective gene program in this experiment.
    primary_references
    [lycopene-p15657364] Carotenoids activate the antioxidant response element transcription system. (2005). https://pubmed.ncbi.nlm.nih.gov/15657364/ DOI: 10.1158/1535-7163.177.4.1
    tissue_or_cell_type
    ARE transcription and phase II enzyme expression

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 442–453

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reporter, expression and dominant-negative transcription-factor experiments · source_derived_draft · unverified_draft

    ### lycopene-are-reporter Lycopene treatment increased ARE-driven reporter expression in transfected cancer cells. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Cells activated a protective gene program in this experiment. organism: Human cancer cell cultures tissue_or_cell_type: ARE transcription and phase II enzyme expression experimental_model: Reporter, expression and dominant-negative transcription-factor experiments limitations: Unidentified derivative extract was active; direct binding of intact lycopene to KEAP1 was not established. exposure: Lycopene and ethanolic derivative extract evidence_span: {"source_cache": "artifacts/lycopene-research/15657364.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32", "start_char": 0, "end_char": 1890, "text_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32"} [lycopene-p15657364] Carotenoids activate the antioxidant response element transcription system. (2005). https://pubmed.ncbi.nlm.nih.gov/15657364/ DOI: 10.1158/1535-7163.177.4.1
    Complete structured claim and evidence

  2. An ethanolic lycopene extract containing unidentified hydrophilic derivatives activated ARE with similar potency to the parent preparation.

    Unidentified hydrophilic derivatives in lycopene extract → Antioxidant response element reporter transcription source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/15657364.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32", "start_char": 0, "end_char": 1890, "text_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32"}
    experimental_model
    Reporter, expression and dominant-negative transcription-factor experiments
    exposure
    Lycopene and ethanolic derivative extract
    limitations
    Unidentified derivative extract was active; direct binding of intact lycopene to KEAP1 was not established.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Human cancer cell cultures
    plain_language
    Products formed from lycopene may contribute to the response.
    primary_references
    [lycopene-p15657364] Carotenoids activate the antioxidant response element transcription system. (2005). https://pubmed.ncbi.nlm.nih.gov/15657364/ DOI: 10.1158/1535-7163.177.4.1
    tissue_or_cell_type
    ARE transcription and phase II enzyme expression

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 468–479

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reporter, expression and dominant-negative transcription-factor experiments · source_derived_draft · unverified_draft

    ### lycopene-derivative-are An ethanolic lycopene extract containing unidentified hydrophilic derivatives activated ARE with similar potency to the parent preparation. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Products formed from lycopene may contribute to the response. organism: Human cancer cell cultures tissue_or_cell_type: ARE transcription and phase II enzyme expression experimental_model: Reporter, expression and dominant-negative transcription-factor experiments limitations: Unidentified derivative extract was active; direct binding of intact lycopene to KEAP1 was not established. exposure: Lycopene and ethanolic derivative extract evidence_span: {"source_cache": "artifacts/lycopene-research/15657364.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32", "start_char": 0, "end_char": 1890, "text_sha256": "a25b93d6074a1e560bf1e163aa70c511e99199b9bb62ccdffdbe70e51fcc7c32"} [lycopene-p15657364] Carotenoids activate the antioxidant response element transcription system. (2005). https://pubmed.ncbi.nlm.nih.gov/15657364/ DOI: 10.1158/1535-7163.177.4.1
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards