Component

Parsley drink in the 2022 apigenin metabolism study

Parsley drink in the 2022 apigenin metabolism study

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. A parsley drink containing 118 micromoles of apiin produced a plasma Apigenin 4′-O-glucuronide peak of 153 ± 61 nM at 4 hours.

    Parsley drink in the 2022 apigenin metabolism study → Apigenin 4′-O-glucuronide Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
    experimental_model
    Four healthy men; 3.2 g parsley powder in 450 mL water.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    A parsley drink containing 118 micromoles of apiin produced a plasma Apigenin 4′-O-glucuronide peak of 153 ± 61 nM at 4 hours.
    primary_references
    Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007
    source_locator
    Reviewed reference api-parsley-glucuronide; Section 3.3.2, Figure 1. These concentrations are of intact conjugates, not free apigenin.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 45–51

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Four healthy men; 3.2 g parsley powder in 450 mL water. · Recorded from source · Recorded from source

    ### api-parsley-glucuronide A parsley drink containing 118 micromoles of apiin produced a plasma Apigenin 4′-O-glucuronide peak of 153 ± 61 nM at 4 hours. Section 3.3.2, Figure 1. These concentrations are of intact conjugates, not free apigenin. Model and exposure: Four healthy men; 3.2 g parsley powder in 450 mL water. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
    Complete structured claim and evidence

  2. A parsley drink containing 118 micromoles of apiin produced a plasma Apigenin 7-O-sulfate peak of 253 ± 202 nM at 4 hours.

    Parsley drink in the 2022 apigenin metabolism study → Apigenin 7-O-sulfate Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
    experimental_model
    Four healthy men; 3.2 g parsley powder in 450 mL water.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    A parsley drink containing 118 micromoles of apiin produced a plasma Apigenin 7-O-sulfate peak of 253 ± 202 nM at 4 hours.
    primary_references
    Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007
    source_locator
    Reviewed reference api-parsley-sulfate; Section 3.3.2, Figure 1. These concentrations are of intact conjugates, not free apigenin.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 53–59

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Four healthy men; 3.2 g parsley powder in 450 mL water. · Recorded from source · Recorded from source

    ### api-parsley-sulfate A parsley drink containing 118 micromoles of apiin produced a plasma Apigenin 7-O-sulfate peak of 253 ± 202 nM at 4 hours. Section 3.3.2, Figure 1. These concentrations are of intact conjugates, not free apigenin. Model and exposure: Four healthy men; 3.2 g parsley powder in 450 mL water. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
    Complete structured claim and evidence

  3. Measured urinary apigenin metabolites after the initial parsley drink averaged 11.2% of ingested flavone equivalents.

    Parsley drink in the 2022 apigenin metabolism study → Human urinary apigenin conjugate recovery Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
    experimental_model
    Four men; 0–24-hour urine.
    interpretation_status
    Recorded from source with stated access limits; ungraded, not independent replication.
    limitations
    Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.
    nutrient_topic
    Apigenin collection; exact intervention and molecular form govern interpretation. · Apigenin
    plain_language
    Measured urinary apigenin metabolites after the initial parsley drink averaged 11.2% of ingested flavone equivalents.
    primary_references
    Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007
    source_locator
    Reviewed reference api-parsley-urine; The larger repeated-intake series gave 17.2 ± 9.8% recovery across 17 intakes, with greater inter-person than within-person variation. Neither figure is an intravenous-reference absolute bioavailability estimate.

    Apigenin: detailed mechanisms of action (reviewed 10 October 2026) · lines 61–67

    AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed. · supports · Four men; 0–24-hour urine. · Recorded from source · Recorded from source

    ### api-parsley-urine Measured urinary apigenin metabolites after the initial parsley drink averaged 11.2% of ingested flavone equivalents. The larger repeated-intake series gave 17.2 ± 9.8% recovery across 17 intakes, with greater inter-person than within-person variation. Neither figure is an intravenous-reference absolute bioavailability estimate. Model and exposure: Four men; 0–24-hour urine. Limitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation. Reference: Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults. | 2022 | https://pubmed.ncbi.nlm.nih.gov/35452808/ | https://doi.org/10.1016/j.freeradbiomed.2022.04.007 | Access: Full original primary-paper PDF, Methods, Results and Tables 1–7 reviewed; authentic-standard HPLC-MS analysis. PDF obtained from a public mirror; DOI and article identity verified.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.