Anxiety symptom score, instrument specified by study: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

Between-group differences reached statistical significance only for tics, not clinician-rated anxiety.
L-Theanine plus vitamin B6, study-specific combination → Anxiety symptom score, instrument specified by study source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/35215501.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2", "start_char": 0, "end_char": 1576, "text_sha256": "68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2"}
experimental_model
Randomized open-label comparative trial
exposure
Theanine plus vitamin B6 versus psychoeducation
limitations
No blinded placebo and no single-ingredient arms. Cannot attribute the effect to either ingredient or prove biochemical synergy.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
34 children with Tourette syndrome or chronic tic disorder and anxiety
plain_language
Improvements within both groups must not be presented as a proven advantage for anxiety.
primary_references
[theanine-p35215501] Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. (2022). https://pubmed.ncbi.nlm.nih.gov/35215501/ DOI: 10.3390/nu14040852
tissue_or_cell_type
Clinician-rated tics and anxiety
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 887–898
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized open-label comparative trial · source_derived_draft · unverified_draft
### theanine-b6-mixture-anxiety-null Between-group differences reached statistical significance only for tics, not clinician-rated anxiety. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Improvements within both groups must not be presented as a proven advantage for anxiety. organism: 34 children with Tourette syndrome or chronic tic disorder and anxiety tissue_or_cell_type: Clinician-rated tics and anxiety experimental_model: Randomized open-label comparative trial limitations: No blinded placebo and no single-ingredient arms. Cannot attribute the effect to either ingredient or prove biochemical synergy. exposure: Theanine plus vitamin B6 versus psychoeducation evidence_span: {"source_cache": "artifacts/theanine-research/35215501.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2", "start_char": 0, "end_char": 1576, "text_sha256": "68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2"} [theanine-p35215501] Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. (2022). https://pubmed.ncbi.nlm.nih.gov/35215501/ DOI: 10.3390/nu14040852
Complete structured claim and evidence
Adjunctive theanine did not outperform placebo on anxiety severity in the GAD trial (p=0.73).
L-Theanine → Anxiety symptom score, instrument specified by study source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/30580081.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837", "start_char": 0, "end_char": 1664, "text_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837"}
experimental_model
Double-blind placebo-controlled adjunctive trial
exposure
450-900 mg/day theanine for eight weeks
limitations
Adjunctive setting with stable medication. Overall negative anxiety and insomnia endpoints; a favorable sleep-satisfaction item is narrower.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
46 people with generalized anxiety disorder on stable antidepressants
plain_language
Laboratory calming signals do not establish treatment efficacy for an anxiety disorder.
primary_references
[theanine-p30580081] L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30580081/ DOI: 10.1016/j.jpsychires.2018.12.014
tissue_or_cell_type
Anxiety and insomnia scales
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 1108–1119
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled adjunctive trial · source_derived_draft · unverified_draft
### theanine-gad-anxiety-null Adjunctive theanine did not outperform placebo on anxiety severity in the GAD trial (p=0.73). Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Laboratory calming signals do not establish treatment efficacy for an anxiety disorder. organism: 46 people with generalized anxiety disorder on stable antidepressants tissue_or_cell_type: Anxiety and insomnia scales experimental_model: Double-blind placebo-controlled adjunctive trial limitations: Adjunctive setting with stable medication. Overall negative anxiety and insomnia endpoints; a favorable sleep-satisfaction item is narrower. exposure: 450-900 mg/day theanine for eight weeks evidence_span: {"source_cache": "artifacts/theanine-research/30580081.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837", "start_char": 0, "end_char": 1664, "text_sha256": "00fa4263444cc6a36149ad1445f431b8930abdb64ca4e30cfce4fc091082a837"} [theanine-p30580081] L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30580081/ DOI: 10.1016/j.jpsychires.2018.12.014
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Anxiety symptom score, instrument specified by study