{"id":"d4af5300-0081-5e7b-af61-d87c3edf6314","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-b6-mixture-anxiety-null","predicate":"did_not_show_significant_between_group_advantage_for","statement":"Between-group differences reached statistical significance only for tics, not clinician-rated anxiety.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"00cd16f9-2ee6-51dc-a1bd-c6639d821ce7","mechanism_event_label":"Improvements within both groups must not be presented as a proven advantage for anxiety.","subject":{"id":"4219b333-24af-57ae-8f51-0f4c9819ce96","slug":"theanine-b6-combination","display_name":"L-Theanine plus vitamin B6, study-specific combination","entity_type_key":"chemical_species"},"object":{"id":"37fd289a-2a64-5e86-8a4c-1edf8218d31e","slug":"anxiety-symptom-score","display_name":"Anxiety symptom score, instrument specified by study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"00cd16f9-2ee6-51dc-a1bd-c6639d821ce7","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-b6-mixture-anxiety-null-event","event_type":"observed_intervention","label":"Improvements within both groups must not be presented as a proven advantage for anxiety.","description":"Between-group differences reached statistical significance only for tics, not clinician-rated anxiety.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4219b333-24af-57ae-8f51-0f4c9819ce96","slug":"theanine-b6-combination","display_name":"L-Theanine plus vitamin B6, study-specific combination","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"37fd289a-2a64-5e86-8a4c-1edf8218d31e","slug":"anxiety-symptom-score","display_name":"Anxiety symptom score, instrument specified by study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/35215501.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2\", \"start_char\": 0, \"end_char\": 1576, \"text_sha256\": \"68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized open-label comparative trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Theanine plus vitamin B6 versus psychoeducation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No blinded placebo and no single-ingredient arms. Cannot attribute the effect to either ingredient or prove biochemical synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"34 children with Tourette syndrome or chronic tic disorder and anxiety","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Improvements within both groups must not be presented as a proven advantage for anxiety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p35215501] Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. (2022). https://pubmed.ncbi.nlm.nih.gov/35215501/ DOI: 10.3390/nu14040852","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinician-rated tics and anxiety","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"82fb4476-4f21-59ab-b47c-755d5690762b","evidence_kind":"source_excerpt","locator":"Lines 887-898","start_line":887,"end_line":898,"excerpt":"### theanine-b6-mixture-anxiety-null\nBetween-group differences reached statistical significance only for tics, not clinician-rated anxiety.\nCondition category: normal\nnutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Improvements within both groups must not be presented as a proven advantage for anxiety.\norganism: 34 children with Tourette syndrome or chronic tic disorder and anxiety\ntissue_or_cell_type: Clinician-rated tics and anxiety\nexperimental_model: Randomized open-label comparative trial\nlimitations: No blinded placebo and no single-ingredient arms. Cannot attribute the effect to either ingredient or prove biochemical synergy.\nexposure: Theanine plus vitamin B6 versus psychoeducation\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/35215501.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2\", \"start_char\": 0, \"end_char\": 1576, \"text_sha256\": \"68809f3eaf29616aa35c472872e3c510e0c8aaf23e8880c43a91f363eaad5ea2\"}\n[theanine-p35215501] Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. (2022). https://pubmed.ncbi.nlm.nih.gov/35215501/ DOI: 10.3390/nu14040852","model_system":"Randomized open-label comparative trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [theanine-p35215501] Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. (2022). https://pubmed.ncbi.nlm.nih.gov/35215501/ DOI: 10.3390/nu14040852","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e2bf3fc8-fc9a-5d50-937a-559a76f8be7d","stable_key":"import-8f12ba85-1a92-5337-a9c0-9cee9b3be90d","title":"L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"c78f2a1961da546cd8d3ae9131a16613aed0d1032904ca19175b0641647142c1","revision_id":"4ec64995-1e5b-5279-9102-f203cb2e29e5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}