Component
Annonaceae fruit and herbal-tea exposure
Species, preparation, dose and limitations are retained on linked claims.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.
Experimental context and source evidence
- dose
- Chronic self-reported Annona muricata/Annona squamosa fruit or tea
- duration
- Retrospective exposure history
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls
- limitations
- Association, recall, combined plant species and unmeasured co-exposures prevent causal attribution to graviola or annonacin.
- nutrient_topic
- Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Graviola / Annona muricata
- organism
- Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls
- plain_language
- In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.
- primary_references
- Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440304/ DOI: 10.1016/s0140-6736(98)10166-6
- route
- Observational dietary exposure
- tissue
- Clinical classification and recalled plant consumption
Graviola (Annona muricata): mechanism of action and interactions (2026-09-20) · lines 77–86
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls · source_derived_draft · unverified_draft
## graviola-human-case-control In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls. Model/species: Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls Tissue/system: Clinical classification and recalled plant consumption Exposure: Chronic self-reported Annona muricata/Annona squamosa fruit or tea Route: Observational dietary exposure Duration: Retrospective exposure history Limits: Association, recall, combined plant species and unmeasured co-exposures prevent causal attribution to graviola or annonacin. Primary reference: Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440304/ DOI: 10.1016/s0140-6736(98)10166-6 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidenceA 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.
Experimental context and source evidence
- dose
- Historical Annonaceae-fruit exposure
- duration
- Cross-sectional severity comparison
- evidence_access
- Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
- evidence_scope
- literature_reviewed; model-specific source-derived curation
- experimental_model
- Caribbean PD group (74) and mainland-France PD group (104)
- limitations
- Exposure was nearly inseparable from population and geography; the study cannot isolate dose, plant species, or causality.
- nutrient_topic
- Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings. · Graviola / Annona muricata
- organism
- Caribbean PD group (74) and mainland-France PD group (104)
- plain_language
- A 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.
- primary_references
- The Clinical Effect of Annonaceae Fruit Consumption on Caribbean Parkinson's Disease Severity. (2026). https://pubmed.ncbi.nlm.nih.gov/42192274/ DOI: 10.1155/bn/8897550
- route
- Observational
- tissue
- UPDRS-III and Mattis Dementia Rating Scale
Graviola (Annona muricata): mechanism of action and interactions (2026-09-20) · lines 88–97
Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text. · supports · Caribbean PD group (74) and mainland-France PD group (104) · source_derived_draft · unverified_draft
## graviola-human-severity A 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients. Model/species: Caribbean PD group (74) and mainland-France PD group (104) Tissue/system: UPDRS-III and Mattis Dementia Rating Scale Exposure: Historical Annonaceae-fruit exposure Route: Observational Duration: Cross-sectional severity comparison Limits: Exposure was nearly inseparable from population and geography; the study cannot isolate dose, plant species, or causality. Primary reference: The Clinical Effect of Annonaceae Fruit Consumption on Caribbean Parkinson's Disease Severity. (2026). https://pubmed.ncbi.nlm.nih.gov/42192274/ DOI: 10.1155/bn/8897550 Access: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.