{"id":"7bf4bbe0-0176-5867-af56-393fea0e61a6","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-human-severity","predicate":"is_associated_with","statement":"A 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0d382b04-f398-5887-b4b3-166a2e8a0781","mechanism_event_label":"A 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.","subject":{"id":"db9226e4-fcee-5c23-b167-8ac5a5bfc0e6","slug":"annonaceae-fruit-and-tea-exposure","display_name":"Annonaceae fruit and herbal-tea exposure","entity_type_key":"botanical"},"object":{"id":"81fa6137-fffe-5346-a29a-6887fc63dab9","slug":"caribbean-parkinson-disease-motor-cognitive-severity","display_name":"Motor and cognitive severity in Caribbean Parkinson disease","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0d382b04-f398-5887-b4b3-166a2e8a0781","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-human-severity-event","event_type":"observed_relationship","label":"A 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.","description":"A 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"db9226e4-fcee-5c23-b167-8ac5a5bfc0e6","slug":"annonaceae-fruit-and-tea-exposure","display_name":"Annonaceae fruit and herbal-tea exposure","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"81fa6137-fffe-5346-a29a-6887fc63dab9","slug":"caribbean-parkinson-disease-motor-cognitive-severity","display_name":"Motor and cognitive severity in Caribbean Parkinson disease","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fc85953a-bdac-5e14-b64f-7e2ce9775a04","slug":"graviola","display_name":"Graviola / Annona muricata","entity_type_key":"botanical"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Historical Annonaceae-fruit exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Cross-sectional severity comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Caribbean PD group (74) and mainland-France PD group (104)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Exposure was nearly inseparable from population and geography; the study cannot isolate dose, plant species, or causality.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"graviola","display_name":"Graviola / Annona muricata","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Caribbean PD group (74) and mainland-France PD group (104)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The Clinical Effect of Annonaceae Fruit Consumption on Caribbean Parkinson's Disease Severity. (2026). https://pubmed.ncbi.nlm.nih.gov/42192274/ DOI: 10.1155/bn/8897550","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Observational","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"UPDRS-III and Mattis Dementia Rating Scale","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4fbfeccd-67d0-535a-a695-9c60df62be9c","evidence_kind":"source_excerpt","locator":"Lines 88-97","start_line":88,"end_line":97,"excerpt":"## graviola-human-severity\nA 2026 adjusted comparison found worse motor and cognitive scores in Caribbean Parkinson-disease patients, 96% of whom reported Annonaceae exposure, than in mainland-France patients.\nModel/species: Caribbean PD group (74) and mainland-France PD group (104)\nTissue/system: UPDRS-III and Mattis Dementia Rating Scale\nExposure: Historical Annonaceae-fruit exposure\nRoute: Observational\nDuration: Cross-sectional severity comparison\nLimits: Exposure was nearly inseparable from population and geography; the study cannot isolate dose, plant species, or causality.\nPrimary reference: The Clinical Effect of Annonaceae Fruit Consumption on Caribbean Parkinson's Disease Severity. (2026). https://pubmed.ncbi.nlm.nih.gov/42192274/ DOI: 10.1155/bn/8897550\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Caribbean PD group (74) and mainland-France PD group (104)","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dde73deb-4328-5cc7-aa41-04b7d845f4fa","stable_key":"import-cea4b417-bb71-5d5d-8fe1-4e175aca750c","title":"Graviola (Annona muricata): mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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