{"id":"361e83c3-bf4c-5bf6-b30c-d94f8c43982b","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-human-case-control","predicate":"is_associated_with","statement":"In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"11582890-84ed-5783-8d2e-fee63d45a369","mechanism_event_label":"In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.","subject":{"id":"db9226e4-fcee-5c23-b167-8ac5a5bfc0e6","slug":"annonaceae-fruit-and-tea-exposure","display_name":"Annonaceae fruit and herbal-tea exposure","entity_type_key":"botanical"},"object":{"id":"613e85dd-39c9-5b6e-95fc-8636f9ed20a4","slug":"guadeloupe-atypical-parkinsonism-psp","display_name":"Atypical parkinsonism and progressive supranuclear palsy in Guadeloupe","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"11582890-84ed-5783-8d2e-fee63d45a369","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-human-case-control-event","event_type":"observed_relationship","label":"In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.","description":"In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"db9226e4-fcee-5c23-b167-8ac5a5bfc0e6","slug":"annonaceae-fruit-and-tea-exposure","display_name":"Annonaceae fruit and herbal-tea exposure","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"613e85dd-39c9-5b6e-95fc-8636f9ed20a4","slug":"guadeloupe-atypical-parkinsonism-psp","display_name":"Atypical parkinsonism and progressive supranuclear palsy in Guadeloupe","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fc85953a-bdac-5e14-b64f-7e2ce9775a04","slug":"graviola","display_name":"Graviola / Annona muricata","entity_type_key":"botanical"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Chronic self-reported Annona muricata/Annona squamosa fruit or tea","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Retrospective exposure history","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association, recall, combined plant species and unmeasured co-exposures prevent causal attribution to graviola or annonacin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Graviola (Annona muricata) chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"graviola","display_name":"Graviola / Annona muricata","entity_type_key":"botanical"}},{"dimension":"organism","value_text":"Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440304/ DOI: 10.1016/s0140-6736(98)10166-6","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Observational dietary exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Clinical classification and recalled plant consumption","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"69de34f1-ab6d-5f98-ba49-70e8d09f2428","evidence_kind":"source_excerpt","locator":"Lines 77-86","start_line":77,"end_line":86,"excerpt":"## graviola-human-case-control\nIn a Guadeloupe case-control study, regular Annonaceae fruit and herbal-tea use was reported much more often by PSP or atypical-parkinsonism cases than by Parkinson-disease cases or controls.\nModel/species: Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls\nTissue/system: Clinical classification and recalled plant consumption\nExposure: Chronic self-reported Annona muricata/Annona squamosa fruit or tea\nRoute: Observational dietary exposure\nDuration: Retrospective exposure history\nLimits: Association, recall, combined plant species and unmeasured co-exposures prevent causal attribution to graviola or annonacin.\nPrimary reference: Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. (1999). https://pubmed.ncbi.nlm.nih.gov/10440304/ DOI: 10.1016/s0140-6736(98)10166-6\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Eighty-seven consecutive Guadeloupe patients with parkinsonism plus frequency-matched controls","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dde73deb-4328-5cc7-aa41-04b7d845f4fa","stable_key":"import-cea4b417-bb71-5d5d-8fe1-4e175aca750c","title":"Graviola (Annona muricata): mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7922ecd3e96739207a7b7b767477da7acf16b0ad177e4d5f9b41dc5606812304","revision_id":"a18d124d-a45d-57d5-8264-29818c1e1a07","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}