Component
ALS functional progression and survival
ALS functional progression and survival. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Creatine did not improve survival or the decline in functional measurements in the ALS trial.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/creatine-research/12666111.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9b668ab22f36cab83a9ccca495012eeff4c953adbd62955fa0efba24a06477ed", "start_char": 0, "end_char": 1367, "text_sha256": "9b668ab22f36cab83a9ccca495012eeff4c953adbd62955fa0efba24a06477ed"}
- experimental_model
- Double-blind placebo-controlled clinical trial
- exposure
- Creatine monohydrate 10 g/day versus placebo
- limitations
- Negative human trial despite a preceding mouse rationale; no inference to every neurological condition.
- nutrient_topic
- Creatine research collection; topical membership is not evidence of a direct dietary effect. · Creatine
- organism
- 175 people with ALS
- plain_language
- An energy-related mechanism and a promising mouse model did not translate into benefit in this human trial.
- primary_references
- [creatine-p12666111] A randomized sequential trial of creatine in amyotrophic lateral sclerosis. (2003). https://pubmed.ncbi.nlm.nih.gov/12666111/ DOI: 10.1002/ana.10554
- tissue_or_cell_type
- Survival and functional progression
Creatine: synthesis, transport, phosphocreatine energetics and nutrient interactions (2026-09-17) · lines 1127–1138
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled clinical trial · source_derived_draft · unverified_draft
### creatine-als-negative Creatine did not improve survival or the decline in functional measurements in the ALS trial. Condition category: normal nutrient_topic: Creatine research collection; topical membership is not evidence of a direct dietary effect. plain_language: An energy-related mechanism and a promising mouse model did not translate into benefit in this human trial. organism: 175 people with ALS tissue_or_cell_type: Survival and functional progression experimental_model: Double-blind placebo-controlled clinical trial limitations: Negative human trial despite a preceding mouse rationale; no inference to every neurological condition. exposure: Creatine monohydrate 10 g/day versus placebo evidence_span: {"source_cache": "artifacts/creatine-research/12666111.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9b668ab22f36cab83a9ccca495012eeff4c953adbd62955fa0efba24a06477ed", "start_char": 0, "end_char": 1367, "text_sha256": "9b668ab22f36cab83a9ccca495012eeff4c953adbd62955fa0efba24a06477ed"} [creatine-p12666111] A randomized sequential trial of creatine in amyotrophic lateral sclerosis. (2003). https://pubmed.ncbi.nlm.nih.gov/12666111/ DOI: 10.1002/ana.10554
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.