{"id":"c5b5a6fe-ce46-5ebe-8248-33910a796c66","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-als-negative","predicate":"did_not_improve","statement":"Creatine did not improve survival or the decline in functional measurements in the ALS trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"eeb7c9c6-5e0b-5699-88e2-5a727d1d41d1","mechanism_event_label":"An energy-related mechanism and a promising mouse model did not translate into benefit in this human trial.","subject":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"object":{"id":"9c7e7b61-93ca-5667-9622-2c1616455474","slug":"als-progression-survival","display_name":"ALS functional progression and survival","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"eeb7c9c6-5e0b-5699-88e2-5a727d1d41d1","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-als-negative-event","event_type":"observed_intervention","label":"An energy-related mechanism and a promising mouse model did not translate into benefit in this human trial.","description":"Creatine did not improve survival or the decline in functional measurements in the ALS trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"399b373f-0034-5f2b-83b7-637eb2678c83","slug":"creatine-monohydrate","display_name":"Creatine monohydrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9c7e7b61-93ca-5667-9622-2c1616455474","slug":"als-progression-survival","display_name":"ALS functional progression and survival","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/12666111.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9b668ab22f36cab83a9ccca495012eeff4c953adbd62955fa0efba24a06477ed\", \"start_char\": 0, \"end_char\": 1367, \"text_sha256\": \"9b668ab22f36cab83a9ccca495012eeff4c953adbd62955fa0efba24a06477ed\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind placebo-controlled clinical trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Creatine monohydrate 10 g/day versus placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Negative human trial despite a preceding mouse rationale; no inference to every neurological condition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"175 people with ALS","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An energy-related mechanism and a promising mouse model did not translate into benefit in this human trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p12666111] A randomized sequential trial of creatine in amyotrophic lateral sclerosis. 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