Component
Human ALDH1L2
Homo sapiens protein; gene perturbations are separate gene entities.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
A human ALDH1L2 construct carrying its N-terminal targeting region localized to mitochondria in transfected cells.
Experimental context and source evidence
- experimental_model
- Fluorescent protein localization
- exposure
- Assay conditions described in the linked primary study.
- limitations
- Localization alone does not measure carbon-disposal flux.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- ALDH1L2 is the mitochondrial counterpart of cytosolic ALDH1L1.
- primary_references
- [krupenko-2010] ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase (2010). https://pubmed.ncbi.nlm.nih.gov/20498374/ DOI: 10.1074/jbc.m110.128843
- tissue_or_cell_type
- A549 cells; corroborating COS-7 host experiments
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1034–1044
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Fluorescent protein localization · source_derived_draft · unverified_draft
### aldh1l2-targeting A human ALDH1L2 construct carrying its N-terminal targeting region localized to mitochondria in transfected cells. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: ALDH1L2 is the mitochondrial counterpart of cytosolic ALDH1L1. organism: Homo sapiens tissue_or_cell_type: A549 cells; corroborating COS-7 host experiments experimental_model: Fluorescent protein localization limitations: Localization alone does not measure carbon-disposal flux. exposure: Assay conditions described in the linked primary study. [krupenko-2010] ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase (2010). https://pubmed.ncbi.nlm.nih.gov/20498374/ DOI: 10.1074/jbc.m110.128843
Complete structured claim and evidence
What acts on it
Human phosphopantetheinyl transferase transfers a CoA-derived prosthetic group to ALDH1L2 Ser375.
Experimental context and source evidence
- cross_nutrient
- B5-derived CoA supplies phosphopantetheine; direct CoA handoff tested, dietary B5 link upstream.
- experimental_model
- Reconstitution and site-directed mutagenesis
- exposure
- Assay conditions described in the linked primary study.
- limitations
- Does not establish dietary B5 deficiency or repletion effects.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- A CoA-derived arm prepares the folate enzyme for catalysis.
- primary_references
- [strickland-2011] Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase (2011). https://pubmed.ncbi.nlm.nih.gov/21238436/ DOI: 10.1016/j.cbi.2011.01.008
- tissue_or_cell_type
- Cell-free
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1046–1057
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Reconstitution and site-directed mutagenesis · source_derived_draft · unverified_draft
### aldh1l2-coa-arm Human phosphopantetheinyl transferase transfers a CoA-derived prosthetic group to ALDH1L2 Ser375. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A CoA-derived arm prepares the folate enzyme for catalysis. organism: Homo sapiens tissue_or_cell_type: Cell-free experimental_model: Reconstitution and site-directed mutagenesis limitations: Does not establish dietary B5 deficiency or repletion effects. exposure: Assay conditions described in the linked primary study. cross_nutrient: B5-derived CoA supplies phosphopantetheine; direct CoA handoff tested, dietary B5 link upstream. [strickland-2011] Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase (2011). https://pubmed.ncbi.nlm.nih.gov/21238436/ DOI: 10.1016/j.cbi.2011.01.008
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.