Component

8-iso-Prostaglandin F2alpha

Context-specific entity; species, compartment and exposure are stated on each claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Urinary 8-iso-PGF2alpha increased 50% versus placebo with c9,t11 supplementation.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human urinary isoprostane during CLA supplementation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Same three-month trial.
    limitations
    Other experiments show CLA can alter marker catabolism; concentration alone does not isolate formation rate.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    A measured lipid-oxidation marker changed.
    primary_references
    Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 438–444

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same three-month trial. · source_derived_draft · unverified_draft

    ## cla-human-c9-marker A measured lipid-oxidation marker changed. Urinary 8-iso-PGF2alpha increased 50% versus placebo with c9,t11 supplementation. Model: Same three-month trial. Limitations: Other experiments show CLA can alter marker catabolism; concentration alone does not isolate formation rate. Evidence access: Primary abstract Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279
    Complete structured claim and evidence

  2. Adding CLA inhibited conversion of 8-iso-PGF2alpha to its dinor metabolite in normal and adrenoleukodystrophy fibroblasts.

    Study-specific mixed-isomer CLA preparations → Human fibroblast isoprostane conversion to dinor metabolite source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human fibroblasts; accompanying rat experiments showed reduced dinor products.
    limitations
    Does not prove all CLA-associated isoprostane increases are harmless or unrelated to oxidation.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    A higher oxidation marker can reflect slower removal.
    primary_references
    Impairment of 8-iso-PGF(2ALPHA) isoprostane metabolism by dietary conjugated linoleic acid (CLA). · 2009 · https://pubmed.ncbi.nlm.nih.gov/19403295/ · DOI 10.1016/j.plefa.2009.02.008

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 358–364

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human fibroblasts; accompanying rat experiments showed reduced dinor products. · source_derived_draft · unverified_draft

    ## cla-isoprostane-catabolism A higher oxidation marker can reflect slower removal. Adding CLA inhibited conversion of 8-iso-PGF2alpha to its dinor metabolite in normal and adrenoleukodystrophy fibroblasts. Model: Human fibroblasts; accompanying rat experiments showed reduced dinor products. Limitations: Does not prove all CLA-associated isoprostane increases are harmless or unrelated to oxidation. Evidence access: Primary abstract Impairment of 8-iso-PGF(2ALPHA) isoprostane metabolism by dietary conjugated linoleic acid (CLA). · 2009 · https://pubmed.ncbi.nlm.nih.gov/19403295/ · DOI 10.1016/j.plefa.2009.02.008
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards