Component

6-Sulfatoxymelatonin / aMT6s

6-Sulfatoxymelatonin / aMT6s. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. SULT1A1 had the strongest tested sulfating activity toward 6-hydroxymelatonin.

    Human sulfotransferase 1A1 / SULT1A1 → 6-Sulfatoxymelatonin / aMT6s source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/26577053.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ab887dc7012d5f393de52ecf842b67282d51b61bac705b9ab187c1a3e24331d5", "start_char": 0, "end_char": 1378, "text_sha256": "ab887dc7012d5f393de52ecf842b67282d51b61bac705b9ab187c1a3e24331d5"}
    experimental_model
    Thirteen human SULT enzymes, labeled cells and tissue cytosols
    exposure
    6-hydroxymelatonin and N-acetylserotonin substrates; sulfate metabolic labeling
    limitations
    Enzyme ranking applies to tested conditions. Sulfation is a separate step from P450 hydroxylation; no dietary sulfur threshold was established.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    Human recombinant enzymes, HepG2 and Caco-2 cells
    plain_language
    The hydroxylated metabolite undergoes another reaction before common urinary measurement.
    primary_references
    [melatonin-p26577053] Sulfation of 6-hydroxymelatonin, N-acetylserotonin and 4-hydroxyramelteon by the human cytosolic sulfotransferases (SULTs). (2016). https://pubmed.ncbi.nlm.nih.gov/26577053/ DOI: 10.3109/00498254.2015.1107656
    tissue_or_cell_type
    Sulfate conjugation

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 630–641

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Thirteen human SULT enzymes, labeled cells and tissue cytosols · source_derived_draft · unverified_draft

    ### melatonin-sult1a1 SULT1A1 had the strongest tested sulfating activity toward 6-hydroxymelatonin. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: The hydroxylated metabolite undergoes another reaction before common urinary measurement. organism: Human recombinant enzymes, HepG2 and Caco-2 cells tissue_or_cell_type: Sulfate conjugation experimental_model: Thirteen human SULT enzymes, labeled cells and tissue cytosols limitations: Enzyme ranking applies to tested conditions. Sulfation is a separate step from P450 hydroxylation; no dietary sulfur threshold was established. exposure: 6-hydroxymelatonin and N-acetylserotonin substrates; sulfate metabolic labeling evidence_span: {"source_cache": "artifacts/melatonin-research/26577053.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ab887dc7012d5f393de52ecf842b67282d51b61bac705b9ab187c1a3e24331d5", "start_char": 0, "end_char": 1378, "text_sha256": "ab887dc7012d5f393de52ecf842b67282d51b61bac705b9ab187c1a3e24331d5"} [melatonin-p26577053] Sulfation of 6-hydroxymelatonin, N-acetylserotonin and 4-hydroxyramelteon by the human cytosolic sulfotransferases (SULTs). (2016). https://pubmed.ncbi.nlm.nih.gov/26577053/ DOI: 10.3109/00498254.2015.1107656
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Atenolol treatment was associated with lower urinary aMT6s and a small increase in blood glucose.

    Atenolol → Urinary 6-sulfatoxymelatonin excretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/melatonin-research/26946962.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992", "start_char": 0, "end_char": 1191, "text_sha256": "ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992"}
    experimental_model
    Nine-week antihypertensive pharmacogenetic cohort analysis
    exposure
    Atenolol treatment; urinary aMT6s normalized to creatinine
    limitations
    Association study; absence of correlation is not proof of no biological role. It does not support a simple linear explanation of atenolol-related glucose changes by lost melatonin.
    nutrient_topic
    Melatonin research collection; topical membership is not evidence of a direct dietary effect. · Melatonin
    organism
    232 hypertensive participants reported as Caucasian in PEAR
    plain_language
    Metabolite excretion and glucose changed during the same treatment.
    primary_references
    [melatonin-p26946962] Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? (2016). https://pubmed.ncbi.nlm.nih.gov/26946962/ DOI: 10.1111/cts.12389
    tissue_or_cell_type
    Urinary melatonin metabolite and blood glucose

    Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17) · lines 1241–1252

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Nine-week antihypertensive pharmacogenetic cohort analysis · source_derived_draft · unverified_draft

    ### melatonin-atenolol-metabolite Atenolol treatment was associated with lower urinary aMT6s and a small increase in blood glucose. Condition category: normal nutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Metabolite excretion and glucose changed during the same treatment. organism: 232 hypertensive participants reported as Caucasian in PEAR tissue_or_cell_type: Urinary melatonin metabolite and blood glucose experimental_model: Nine-week antihypertensive pharmacogenetic cohort analysis limitations: Association study; absence of correlation is not proof of no biological role. It does not support a simple linear explanation of atenolol-related glucose changes by lost melatonin. exposure: Atenolol treatment; urinary aMT6s normalized to creatinine evidence_span: {"source_cache": "artifacts/melatonin-research/26946962.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992", "start_char": 0, "end_char": 1191, "text_sha256": "ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992"} [melatonin-p26946962] Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? (2016). https://pubmed.ncbi.nlm.nih.gov/26946962/ DOI: 10.1111/cts.12389
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards