{"id":"20f9b081-7307-5990-b63d-fa75cf685150","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-atenolol-metabolite","predicate":"associated_with_reduced","statement":"Atenolol treatment was associated with lower urinary aMT6s and a small increase in blood glucose.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"dfc210a5-f22a-50f5-8128-8390609323af","mechanism_event_label":"Metabolite excretion and glucose changed during the same treatment.","subject":{"id":"5af8304e-4059-5331-88c9-4ecf49ab805f","slug":"atenolol","display_name":"Atenolol","entity_type_key":"small_molecule"},"object":{"id":"e0d2b3a6-25b1-5019-bd19-488c852fbd52","slug":"urinary-6-sulfatoxymelatonin","display_name":"Urinary 6-sulfatoxymelatonin excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dfc210a5-f22a-50f5-8128-8390609323af","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-atenolol-metabolite-event","event_type":"observed_intervention","label":"Metabolite excretion and glucose changed during the same treatment.","description":"Atenolol treatment was associated with lower urinary aMT6s and a small increase in blood glucose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"195f17f7-1880-5336-8d7c-d491f72cbee7","slug":"6-sulfatoxymelatonin","display_name":"6-Sulfatoxymelatonin / aMT6s","entity_type_key":"small_molecule"},"role":"measured_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5af8304e-4059-5331-88c9-4ecf49ab805f","slug":"atenolol","display_name":"Atenolol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e0d2b3a6-25b1-5019-bd19-488c852fbd52","slug":"urinary-6-sulfatoxymelatonin","display_name":"Urinary 6-sulfatoxymelatonin excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/26946962.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992\", \"start_char\": 0, \"end_char\": 1191, \"text_sha256\": \"ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nine-week antihypertensive pharmacogenetic cohort analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Atenolol treatment; urinary aMT6s normalized to creatinine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association study; absence of correlation is not proof of no biological role. It does not support a simple linear explanation of atenolol-related glucose changes by lost melatonin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"232 hypertensive participants reported as Caucasian in PEAR","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Metabolite excretion and glucose changed during the same treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p26946962] Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? (2016). https://pubmed.ncbi.nlm.nih.gov/26946962/ DOI: 10.1111/cts.12389","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urinary melatonin metabolite and blood glucose","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"72a5bcf4-45e9-515c-bd38-62fcd3c717c7","evidence_kind":"source_excerpt","locator":"Lines 1241-1252","start_line":1241,"end_line":1252,"excerpt":"### melatonin-atenolol-metabolite\nAtenolol treatment was associated with lower urinary aMT6s and a small increase in blood glucose.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Metabolite excretion and glucose changed during the same treatment.\norganism: 232 hypertensive participants reported as Caucasian in PEAR\ntissue_or_cell_type: Urinary melatonin metabolite and blood glucose\nexperimental_model: Nine-week antihypertensive pharmacogenetic cohort analysis\nlimitations: Association study; absence of correlation is not proof of no biological role. It does not support a simple linear explanation of atenolol-related glucose changes by lost melatonin.\nexposure: Atenolol treatment; urinary aMT6s normalized to creatinine\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/26946962.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992\", \"start_char\": 0, \"end_char\": 1191, \"text_sha256\": \"ad9bf60e8f57ef2ec9fe9e4b74b848b9cc0711fe00cf5a9959bf489dd9c8f992\"}\n[melatonin-p26946962] Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? (2016). https://pubmed.ncbi.nlm.nih.gov/26946962/ DOI: 10.1111/cts.12389","model_system":"Nine-week antihypertensive pharmacogenetic cohort analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p26946962] Melatonin Pathway and Atenolol-Related Glucose Dysregulation: Is There a Correlation? (2016). https://pubmed.ncbi.nlm.nih.gov/26946962/ DOI: 10.1111/cts.12389","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff4f279d263f95a69da8e7e8a6c6318ab6ba1b55254dbbda1bfa9ce437e1db80","revision_id":"0318eef8-ff38-513e-8ffa-458146ca5e77","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}