Component
6-Gingerol 4-prime-O-glucuronide
Experimental species, exposure and limitations are retained on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.
Experimental context and source evidence
- dose
- 6-Gingerol with UDP-glucuronic acid; exact concentrations not in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Human intestinal microsomes
- limitations
- Phenolic product formation in this preparation is not absolute oral bioavailability or a proven clinical interaction.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Human intestinal microsomes
- plain_language
- UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.
- primary_references
- Microsomal hydroxylation and glucuronidation of [6]-gingerol. (2006). https://pubmed.ncbi.nlm.nih.gov/17090120/ DOI: 10.1021/jf062235l
- route
- In vitro microsomal incubation
- tissue
- Intestinal microsomal preparation
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 272–281
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Human intestinal microsomes · source_derived_draft · unverified_draft
## gingerols-6-intestinal-glucuronide UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide. Model/species: Human intestinal microsomes Tissue: Intestinal microsomal preparation Exposure: 6-Gingerol with UDP-glucuronic acid; exact concentrations not in accessed abstract Route: In vitro microsomal incubation Duration: Not specified in accessed abstract Limits: Phenolic product formation in this preparation is not absolute oral bioavailability or a proven clinical interaction. Primary reference: Microsomal hydroxylation and glucuronidation of [6]-gingerol. (2006). https://pubmed.ncbi.nlm.nih.gov/17090120/ DOI: 10.1021/jf062235l Access: Primary PubMed abstract.
Complete structured claim and evidenceHuman UGT2B7 was a principal contributor to 6-gingerol 4-prime-O-glucuronide formation in the enzyme comparison.
Experimental context and source evidence
- dose
- Individual 6-, 8- or 10-gingerol with UDP-glucuronic acid; exact concentration series not in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Human liver microsomes and expressed human UGT enzymes
- limitations
- UGT2B7 favors but is not exclusive to 4-prime conjugation; UGT1A9 mainly forms 5-O conjugates. Shared UGT substrates do not prove competition in people.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Human liver microsomes and expressed human UGT enzymes
- plain_language
- Human UGT2B7 was a principal contributor to 6-gingerol 4-prime-O-glucuronide formation in the enzyme comparison.
- primary_references
- Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7. (2015). https://pubmed.ncbi.nlm.nih.gov/25496264/ DOI: 10.1111/jphp.12351
- route
- In vitro incubation
- tissue
- Hepatic and recombinant enzyme preparations
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 283–292
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Human liver microsomes and expressed human UGT enzymes · source_derived_draft · unverified_draft
## gingerols-6-ugt2b7 Human UGT2B7 was a principal contributor to 6-gingerol 4-prime-O-glucuronide formation in the enzyme comparison. Model/species: Human liver microsomes and expressed human UGT enzymes Tissue: Hepatic and recombinant enzyme preparations Exposure: Individual 6-, 8- or 10-gingerol with UDP-glucuronic acid; exact concentration series not in accessed abstract Route: In vitro incubation Duration: Not specified in accessed abstract Limits: UGT2B7 favors but is not exclusive to 4-prime conjugation; UGT1A9 mainly forms 5-O conjugates. Shared UGT substrates do not prove competition in people. Primary reference: Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7. (2015). https://pubmed.ncbi.nlm.nih.gov/25496264/ DOI: 10.1111/jphp.12351 Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.