{"id":"d02f6462-efda-55dd-9c20-6407e62387ad","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-intestinal-glucuronide","predicate":"is_glucuronidated_to","statement":"UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"2fb7becf-5950-560c-ac3b-366d8be4aae8","mechanism_event_label":"UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"6d766e7b-31a1-5984-8f12-25a085c64017","slug":"6-gingerol-4prime-o-glucuronide","display_name":"6-Gingerol 4-prime-O-glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"2fb7becf-5950-560c-ac3b-366d8be4aae8","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-intestinal-glucuronide-event","event_type":"observed_relationship","label":"UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.","description":"UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6d766e7b-31a1-5984-8f12-25a085c64017","slug":"6-gingerol-4prime-o-glucuronide","display_name":"6-Gingerol 4-prime-O-glucuronide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fea4f3f0-7c05-59a2-9332-445b9d4f8fb0","slug":"udp-glucuronic-acid","display_name":"UDP-glucuronic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6-Gingerol with UDP-glucuronic acid; exact concentrations not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human intestinal microsomes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Phenolic product formation in this preparation is not absolute oral bioavailability or a proven clinical interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human intestinal microsomes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"UDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microsomal hydroxylation and glucuronidation of [6]-gingerol. (2006). https://pubmed.ncbi.nlm.nih.gov/17090120/ DOI: 10.1021/jf062235l","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro microsomal incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Intestinal microsomal preparation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1db77ee3-dcb4-5739-816a-8c55f0c27a41","evidence_kind":"source_excerpt","locator":"Lines 272-281","start_line":272,"end_line":281,"excerpt":"## gingerols-6-intestinal-glucuronide\nUDP-glucuronic-acid-fortified human intestinal microsomes formed the phenolic 6-gingerol glucuronide.\nModel/species: Human intestinal microsomes\nTissue: Intestinal microsomal preparation\nExposure: 6-Gingerol with UDP-glucuronic acid; exact concentrations not in accessed abstract\nRoute: In vitro microsomal incubation\nDuration: Not specified in accessed abstract\nLimits: Phenolic product formation in this preparation is not absolute oral bioavailability or a proven clinical interaction.\nPrimary reference: Microsomal hydroxylation and glucuronidation of [6]-gingerol. (2006). https://pubmed.ncbi.nlm.nih.gov/17090120/ DOI: 10.1021/jf062235l\nAccess: Primary PubMed abstract.","model_system":"Human intestinal microsomes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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