Component
Whole-body lipolytic flux
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Lipolysis increased approximately 2.5-fold over 60 hours.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Six men; isotope tracers and indirect calorimetry during a 60-hour fast.
- limitations
- Protocol-specific fluxes; no universal hour-by-hour threshold.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- Stored fat supplied more circulating fuel.
- primary_references
- Fuel and energy metabolism in fasting humans. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8017334/ · DOI 10.1093/ajcn/60.1.29
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 24–30
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Six men; isotope tracers and indirect calorimetry during a 60-hour fast. · source_derived_draft · unverified_draft
## fast-lipolysis Stored fat supplied more circulating fuel. Lipolysis increased approximately 2.5-fold over 60 hours. Model: Six men; isotope tracers and indirect calorimetry during a 60-hour fast. Limitations: Protocol-specific fluxes; no universal hour-by-hour threshold. Evidence access: Primary abstract Fuel and energy metabolism in fasting humans. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8017334/ · DOI 10.1093/ajcn/60.1.29
Complete structured claim and evidence
Where it participates (unsigned role)
Adipose PDE3B transcript levels decreased after fasting, with and without GH blockade.
Experimental context and source evidence
- evidence_access
- Primary full-text Results: Regulation of lipolysis, DOI 10.1210/jc.2016-3835
- experimental_model
- Nine obese men; adipose biopsy after 72-hour fast.
- limitations
- Transcript level is not direct PDE3B enzyme activity.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- A molecular brake on fat release changed.
- primary_references
- Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 224–230
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Nine obese men; adipose biopsy after 72-hour fast. · source_derived_draft · unverified_draft
## fast-adipose-pde3b A molecular brake on fat release changed. Adipose PDE3B transcript levels decreased after fasting, with and without GH blockade. Model: Nine obese men; adipose biopsy after 72-hour fast. Limitations: Transcript level is not direct PDE3B enzyme activity. Evidence access: Primary full-text Results: Regulation of lipolysis, DOI 10.1210/jc.2016-3835 Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.