Component
Whole-body de novo arginine synthesis
Whole-body de novo arginine synthesis. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Despite reduced renal function, whole-body de novo arginine synthesis appeared preserved in the ESRD patients.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/citrulline-research/10791996.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "80c58ac3892fcee1c04da2c05c0005b4b40e6c3479127a3da3528e46162c7f49", "start_char": 0, "end_char": 1285, "text_sha256": "80c58ac3892fcee1c04da2c05c0005b4b40e6c3479127a3da3528e46162c7f49"}
- experimental_model
- Stable-isotope kinetic study around hemodialysis
- exposure
- Two pre- and two postdialysis tracer studies
- limitations
- Whole-body flux does not locate the compensating tissues; elevated plasma concentration is not evidence of adequate function in every compartment.
- nutrient_topic
- Citrulline research collection; topical membership is not evidence of a direct dietary effect. · L-Citrulline
- organism
- Human, six end-stage renal disease patients
- plain_language
- Loss of kidney function did not abolish all arginine synthesis in this small study.
- primary_references
- [citrulline-p10791996] Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients. (2000). https://pubmed.ncbi.nlm.nih.gov/10791996/ DOI: 10.1172/jci7199
- tissue_or_cell_type
- Whole-body arginine and NO metabolism
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Citrulline: arginine recycling, nitrogen disposal and nutrient connections (2026-09-17) · lines 1009–1020
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Stable-isotope kinetic study around hemodialysis · source_derived_draft · unverified_draft
### citrulline-renal-arginine-preserved Despite reduced renal function, whole-body de novo arginine synthesis appeared preserved in the ESRD patients. Condition category: biomarker_context nutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect. plain_language: Loss of kidney function did not abolish all arginine synthesis in this small study. organism: Human, six end-stage renal disease patients tissue_or_cell_type: Whole-body arginine and NO metabolism experimental_model: Stable-isotope kinetic study around hemodialysis limitations: Whole-body flux does not locate the compensating tissues; elevated plasma concentration is not evidence of adequate function in every compartment. exposure: Two pre- and two postdialysis tracer studies evidence_span: {"source_cache": "artifacts/citrulline-research/10791996.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "80c58ac3892fcee1c04da2c05c0005b4b40e6c3479127a3da3528e46162c7f49", "start_char": 0, "end_char": 1285, "text_sha256": "80c58ac3892fcee1c04da2c05c0005b4b40e6c3479127a3da3528e46162c7f49"} [citrulline-p10791996] Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients. (2000). https://pubmed.ncbi.nlm.nih.gov/10791996/ DOI: 10.1172/jci7199
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.