{"id":"58747390-5e52-5351-82c9-d47687e62072","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-renal-arginine-preserved","predicate":"continued_to_supply","statement":"Despite reduced renal function, whole-body de novo arginine synthesis appeared preserved in the ESRD patients.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b79ba4e9-95cb-55dd-9eae-15b35c55b20f","mechanism_event_label":"Loss of kidney function did not abolish all arginine synthesis in this small study.","subject":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"object":{"id":"983654cc-848e-5c9f-900b-2967c8024c4f","slug":"whole-body-arginine-synthesis","display_name":"Whole-body de novo arginine synthesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b79ba4e9-95cb-55dd-9eae-15b35c55b20f","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-renal-arginine-preserved-event","event_type":"biochemical_relationship","label":"Loss of kidney function did not abolish all arginine synthesis in this small study.","description":"Despite reduced renal function, whole-body de novo arginine synthesis appeared preserved in the ESRD patients.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"983654cc-848e-5c9f-900b-2967c8024c4f","slug":"whole-body-arginine-synthesis","display_name":"Whole-body de novo arginine synthesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/citrulline-research/10791996.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"80c58ac3892fcee1c04da2c05c0005b4b40e6c3479127a3da3528e46162c7f49\", \"start_char\": 0, \"end_char\": 1285, \"text_sha256\": \"80c58ac3892fcee1c04da2c05c0005b4b40e6c3479127a3da3528e46162c7f49\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stable-isotope kinetic study around hemodialysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Two pre- and two postdialysis tracer studies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole-body flux does not locate the compensating tissues; elevated plasma concentration is not evidence of adequate function in every compartment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Citrulline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, six end-stage renal disease patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Loss of kidney function did not abolish all arginine synthesis in this small study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[citrulline-p10791996] Arginine, citrulline, and nitric oxide metabolism in end-stage renal disease patients. 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