Component
Vitamin K epoxide recycling
Vitamin K epoxide recycling. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Silencing the identified VKORC1 gene reduced vitamin K epoxide reductase activity; recombinant expression restored warfarin-sensitive enzyme activity.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/k2-research/14765195.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "32f373fc0363ed079e580b2d47a3cb36c82b46871860fc6740b0285e23936496", "start_char": 0, "end_char": 1385, "text_sha256": "32f373fc0363ed079e580b2d47a3cb36c82b46871860fc6740b0285e23936496"}
- experimental_model
- siRNA identification and recombinant expression
- exposure
- Gene silencing, enzyme expression and warfarin sensitivity
- limitations
- Gene-discovery experiments; later structural understanding supersedes the original minimal topology description.
- nutrient_topic
- Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
- organism
- Human VKORC1 and insect-cell expression
- plain_language
- The used vitamin K cofactor can be recycled instead of being replaced after every reaction.
- primary_references
- [k2-p14765195] Identification of the gene for vitamin K epoxide reductase. (2004). https://pubmed.ncbi.nlm.nih.gov/14765195/ DOI: 10.1038/nature02254
- tissue_or_cell_type
- Vitamin K recycling enzyme
Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 435–446
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · siRNA identification and recombinant expression · source_derived_draft · unverified_draft
### k2-vkor-recycling Silencing the identified VKORC1 gene reduced vitamin K epoxide reductase activity; recombinant expression restored warfarin-sensitive enzyme activity. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The used vitamin K cofactor can be recycled instead of being replaced after every reaction. organism: Human VKORC1 and insect-cell expression tissue_or_cell_type: Vitamin K recycling enzyme experimental_model: siRNA identification and recombinant expression limitations: Gene-discovery experiments; later structural understanding supersedes the original minimal topology description. exposure: Gene silencing, enzyme expression and warfarin sensitivity evidence_span: {"source_cache": "artifacts/k2-research/14765195.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "32f373fc0363ed079e580b2d47a3cb36c82b46871860fc6740b0285e23936496", "start_char": 0, "end_char": 1385, "text_sha256": "32f373fc0363ed079e580b2d47a3cb36c82b46871860fc6740b0285e23936496"} [k2-p14765195] Identification of the gene for vitamin K epoxide reductase. (2004). https://pubmed.ncbi.nlm.nih.gov/14765195/ DOI: 10.1038/nature02254
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.