Component
Vitamin E status classification
Vitamin E status classification. Read linked claims for the population, experiment and limits.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
In the cirrhosis cohort, cholesterol normalization classified fewer patients as vitamin E deficient than absolute concentrations; the authors cautioned that the ratio could obscure reduced status in advanced liver disease.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Observational comparison of 85 cirrhosis and 50 noncirrhotic liver-disease patients
- exposure
- Absolute vitamin E compared with vitamin E/cholesterol ratio using study-specific healthy-control reference limits.
- limitations
- No direct tissue adequacy test. Cirrhosis changes lipid handling; neither an absolute concentration nor a normalized ratio alone establishes cellular function.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- Lipid correction is useful context, but it can also conceal a problem when liver disease changes both measurements.
- primary_references
- [e-clin-cirrhosis1999] Vitamin E status in patients with liver cirrhosis: normal or deficient? (1999). https://pubmed.ncbi.nlm.nih.gov/9920150/ DOI: 10.1016/s0026-0495(99)90015-x
- tissue_or_cell_type
- Serum and liver-disease context
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1245–1256
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Observational comparison of 85 cirrhosis and 50 noncirrhotic liver-disease patients · source_derived_draft · unverified_draft
### e-clin-cirrhosis-ratio-boundary In the cirrhosis cohort, cholesterol normalization classified fewer patients as vitamin E deficient than absolute concentrations; the authors cautioned that the ratio could obscure reduced status in advanced liver disease. Condition category: biomarker_context nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: Lipid correction is useful context, but it can also conceal a problem when liver disease changes both measurements. organism: Homo sapiens tissue_or_cell_type: Serum and liver-disease context experimental_model: Observational comparison of 85 cirrhosis and 50 noncirrhotic liver-disease patients limitations: No direct tissue adequacy test. Cirrhosis changes lipid handling; neither an absolute concentration nor a normalized ratio alone establishes cellular function. exposure: Absolute vitamin E compared with vitamin E/cholesterol ratio using study-specific healthy-control reference limits. cross_nutrient: false [e-clin-cirrhosis1999] Vitamin E status in patients with liver cirrhosis: normal or deficient? (1999). https://pubmed.ncbi.nlm.nih.gov/9920150/ DOI: 10.1016/s0026-0495(99)90015-x
Complete structured claim and evidenceAmong 59 specimens with alpha-tocopherol below 5 mg/L, 28 were reclassified within the study lipid-ratio reference interval after cholesterol and triglycerides were considered.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Original patient-specimen laboratory analysis within an article indexed as review
- exposure
- Lipid-adjusted assessment; reference specimens n=307; low-concentration subset n=59.
- limitations
- Laboratory reclassification, not a direct tissue-deficiency gold standard. The abstract has an apparent typo in a separate high-concentration denominator; that statistic is not used here.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Homo sapiens
- plain_language
- A low vitamin E concentration can look different once blood lipids are considered.
- primary_references
- [e-clin-winbauer1999] Evaluating serum alpha-tocopherol (vitamin E) in terms of a lipid ratio. (1999). https://pubmed.ncbi.nlm.nih.gov/10440582/
- tissue_or_cell_type
- Serum
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 1232–1243
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Original patient-specimen laboratory analysis within an article indexed as review · source_derived_draft · unverified_draft
### e-clin-lipid-ratio-reclassification Among 59 specimens with alpha-tocopherol below 5 mg/L, 28 were reclassified within the study lipid-ratio reference interval after cholesterol and triglycerides were considered. Condition category: biomarker_context nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: A low vitamin E concentration can look different once blood lipids are considered. organism: Homo sapiens tissue_or_cell_type: Serum experimental_model: Original patient-specimen laboratory analysis within an article indexed as review limitations: Laboratory reclassification, not a direct tissue-deficiency gold standard. The abstract has an apparent typo in a separate high-concentration denominator; that statistic is not used here. exposure: Lipid-adjusted assessment; reference specimens n=307; low-concentration subset n=59. cross_nutrient: false [e-clin-winbauer1999] Evaluating serum alpha-tocopherol (vitamin E) in terms of a lipid ratio. (1999). https://pubmed.ncbi.nlm.nih.gov/10440582/
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.