{"id":"20073bbf-fde1-5c3d-9963-774dacc1db5d","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-lipid-ratio-reclassification","predicate":"lipid_adjustment_changes","statement":"Among 59 specimens with alpha-tocopherol below 5 mg/L, 28 were reclassified within the study lipid-ratio reference interval after cholesterol and triglycerides were considered.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"402bf56e-1450-5bfb-ae66-32a2a1611603","mechanism_event_label":"A low vitamin E concentration can look different once blood lipids are considered.","subject":{"id":"d3a1b93d-0a2c-5d1b-b672-5e4ef4b09a10","slug":"cholesterol","display_name":"Cholesterol","entity_type_key":"lipid"},"object":{"id":"c3d98784-c6b5-5f67-a14d-260f8ded4e5d","slug":"vitamin-e-status-classification","display_name":"Vitamin E status classification","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"402bf56e-1450-5bfb-ae66-32a2a1611603","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-lipid-ratio-reclassification-event","event_type":"observed_intervention","label":"A low vitamin E concentration can look different once blood lipids are considered.","description":"Among 59 specimens with alpha-tocopherol below 5 mg/L, 28 were reclassified within the study lipid-ratio reference interval after cholesterol and triglycerides were considered.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"measured_vitamer","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d3a1b93d-0a2c-5d1b-b672-5e4ef4b09a10","slug":"cholesterol","display_name":"Cholesterol","entity_type_key":"lipid"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c3d98784-c6b5-5f67-a14d-260f8ded4e5d","slug":"vitamin-e-status-classification","display_name":"Vitamin E status classification","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Original patient-specimen laboratory analysis within an article indexed as review","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lipid-adjusted assessment; reference specimens n=307; low-concentration subset n=59.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Laboratory reclassification, not a direct tissue-deficiency gold standard. The abstract has an apparent typo in a separate high-concentration denominator; that statistic is not used here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A low vitamin E concentration can look different once blood lipids are considered.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-winbauer1999] Evaluating serum alpha-tocopherol (vitamin E) in terms of a lipid ratio. (1999). https://pubmed.ncbi.nlm.nih.gov/10440582/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1ca87635-5655-5968-8318-87c4f9f73a9a","evidence_kind":"source_excerpt","locator":"Lines 1232-1243","start_line":1232,"end_line":1243,"excerpt":"### e-clin-lipid-ratio-reclassification\nAmong 59 specimens with alpha-tocopherol below 5 mg/L, 28 were reclassified within the study lipid-ratio reference interval after cholesterol and triglycerides were considered.\nCondition category: biomarker_context\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A low vitamin E concentration can look different once blood lipids are considered.\norganism: Homo sapiens\ntissue_or_cell_type: Serum\nexperimental_model: Original patient-specimen laboratory analysis within an article indexed as review\nlimitations: Laboratory reclassification, not a direct tissue-deficiency gold standard. The abstract has an apparent typo in a separate high-concentration denominator; that statistic is not used here.\nexposure: Lipid-adjusted assessment; reference specimens n=307; low-concentration subset n=59.\ncross_nutrient: false\n[e-clin-winbauer1999] Evaluating serum alpha-tocopherol (vitamin E) in terms of a lipid ratio. (1999). https://pubmed.ncbi.nlm.nih.gov/10440582/","model_system":"Original patient-specimen laboratory analysis within an article indexed as review","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-winbauer1999] Evaluating serum alpha-tocopherol (vitamin E) in terms of a lipid ratio. (1999). https://pubmed.ncbi.nlm.nih.gov/10440582/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}