Component

Vascular smooth muscle cell matrix calcification

Vascular smooth muscle cell matrix calcification. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Full-length MGP and its gamma-carboxylated domain inhibited calcium deposition in the tested vascular-cell model.

    Gamma-carboxylated matrix Gla protein → Vascular smooth muscle cell matrix calcification source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/17848178.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27", "start_char": 0, "end_char": 1745, "text_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27"}
    experimental_model
    Human vascular-cell calcification and synthetic-peptide assays
    exposure
    Elevated calcium, warfarin, K1 and modified MGP peptides
    limitations
    Vitamin K1 intervention in cells; K2-specific efficacy and human arterial reversal were not tested.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    Human vascular smooth muscle cells
    plain_language
    One vitamin K-dependent protein modification contributes to local control of mineral deposition.
    primary_references
    [k2-p17848178] Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. (2007). https://pubmed.ncbi.nlm.nih.gov/17848178/ DOI: 10.1111/j.1538-7836.2007.02758.x
    tissue_or_cell_type
    Extracellular matrix and vesicle-like surfaces

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 513–524

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human vascular-cell calcification and synthetic-peptide assays · source_derived_draft · unverified_draft

    ### k2-mgp-gla Full-length MGP and its gamma-carboxylated domain inhibited calcium deposition in the tested vascular-cell model. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: One vitamin K-dependent protein modification contributes to local control of mineral deposition. organism: Human vascular smooth muscle cells tissue_or_cell_type: Extracellular matrix and vesicle-like surfaces experimental_model: Human vascular-cell calcification and synthetic-peptide assays limitations: Vitamin K1 intervention in cells; K2-specific efficacy and human arterial reversal were not tested. exposure: Elevated calcium, warfarin, K1 and modified MGP peptides evidence_span: {"source_cache": "artifacts/k2-research/17848178.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27", "start_char": 0, "end_char": 1745, "text_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27"} [k2-p17848178] Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. (2007). https://pubmed.ncbi.nlm.nih.gov/17848178/ DOI: 10.1111/j.1538-7836.2007.02758.x
    Complete structured claim and evidence

  2. The phosphorylated serine motif also inhibited calcification and bound cell surfaces and vesicle-like structures.

    Human matrix Gla protein / MGP → Vascular smooth muscle cell matrix calcification source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/17848178.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27", "start_char": 0, "end_char": 1745, "text_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27"}
    experimental_model
    Human vascular-cell calcification and synthetic-peptide assays
    exposure
    Elevated calcium, warfarin, K1 and modified MGP peptides
    limitations
    Vitamin K1 intervention in cells; K2-specific efficacy and human arterial reversal were not tested.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    Human vascular smooth muscle cells
    plain_language
    Carboxylation is not the only modification contributing to MGP function.
    primary_references
    [k2-p17848178] Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. (2007). https://pubmed.ncbi.nlm.nih.gov/17848178/ DOI: 10.1111/j.1538-7836.2007.02758.x
    tissue_or_cell_type
    Extracellular matrix and vesicle-like surfaces

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 526–537

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human vascular-cell calcification and synthetic-peptide assays · source_derived_draft · unverified_draft

    ### k2-mgp-phosphorylation The phosphorylated serine motif also inhibited calcification and bound cell surfaces and vesicle-like structures. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Carboxylation is not the only modification contributing to MGP function. organism: Human vascular smooth muscle cells tissue_or_cell_type: Extracellular matrix and vesicle-like surfaces experimental_model: Human vascular-cell calcification and synthetic-peptide assays limitations: Vitamin K1 intervention in cells; K2-specific efficacy and human arterial reversal were not tested. exposure: Elevated calcium, warfarin, K1 and modified MGP peptides evidence_span: {"source_cache": "artifacts/k2-research/17848178.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27", "start_char": 0, "end_char": 1745, "text_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27"} [k2-p17848178] Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. (2007). https://pubmed.ncbi.nlm.nih.gov/17848178/ DOI: 10.1111/j.1538-7836.2007.02758.x
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Warfarin-treated vascular cells produced uncarboxylated MGP and accumulated more calcium salts than controls.

    Warfarin → Uncarboxylated matrix Gla protein source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/k2-research/17848178.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27", "start_char": 0, "end_char": 1745, "text_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27"}
    experimental_model
    Human vascular-cell calcification and synthetic-peptide assays
    exposure
    Elevated calcium, warfarin, K1 and modified MGP peptides
    limitations
    Vitamin K1 intervention in cells; K2-specific efficacy and human arterial reversal were not tested.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    Human vascular smooth muscle cells
    plain_language
    Changing the vitamin K cycle changed the protein state and the mineral-deposition outcome in these cells.
    primary_references
    [k2-p17848178] Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. (2007). https://pubmed.ncbi.nlm.nih.gov/17848178/ DOI: 10.1111/j.1538-7836.2007.02758.x
    tissue_or_cell_type
    Extracellular matrix and vesicle-like surfaces
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 539–550

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human vascular-cell calcification and synthetic-peptide assays · source_derived_draft · unverified_draft

    ### k2-warfarin-mgp Warfarin-treated vascular cells produced uncarboxylated MGP and accumulated more calcium salts than controls. Condition category: machinery_impairment nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Changing the vitamin K cycle changed the protein state and the mineral-deposition outcome in these cells. organism: Human vascular smooth muscle cells tissue_or_cell_type: Extracellular matrix and vesicle-like surfaces experimental_model: Human vascular-cell calcification and synthetic-peptide assays limitations: Vitamin K1 intervention in cells; K2-specific efficacy and human arterial reversal were not tested. exposure: Elevated calcium, warfarin, K1 and modified MGP peptides evidence_span: {"source_cache": "artifacts/k2-research/17848178.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27", "start_char": 0, "end_char": 1745, "text_sha256": "d2d79c43cc8142d6dc8f1eab4ac99b05ceb01e50e5afb41f5ca75aec732cba27"} [k2-p17848178] Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification. (2007). https://pubmed.ncbi.nlm.nih.gov/17848178/ DOI: 10.1111/j.1538-7836.2007.02758.x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards