Component
Vagal afferent activity
Vagal afferent activity. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Bilateral cervical or subdiaphragmatic vagotomy attenuated the decreases in brown adipose tissue sympathetic nerve activity and thermogenesis evoked by nanoinjection of resiniferatoxin into the nucleus tractus solitarius but did not prevent the decreases evoked by intravenous dihydrocapsaicin, consistent with a non-vagal pathway through which systemic TRPV1 agonists can inhibit brown adipose tissue thermogenesis.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/29590555.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "947ba9408e8bbaecee08ba0b2018014faa1d26d3c1fdf8df063e92911e53e19a", "start_char": 0, "end_char": 1882, "text_sha256": "947ba9408e8bbaecee08ba0b2018014faa1d26d3c1fdf8df063e92911e53e19a"}
- experimental_model
- Urethane-chloralose-anaesthetised rats with nucleus tractus solitarius nanoinjection, sympathetic nerve recording and vagotomy
- exposure
- Intravenous dihydrocapsaicin, against resiniferatoxin nanoinjected into the nucleus tractus solitarius, with capsazepine and bilateral cervical or subdiaphragmatic vagotomy
- limitations
- The vagotomy control separates a central vagal route from whatever systemic dihydrocapsaicin uses. Anaesthetised animals, so the cardiovascular numbers are not directly comparable with the conscious studies here.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Rat
- plain_language
- Cutting the vagus nerve stopped the brain-injected agonist working but not the injected one, so they reach the heater by different roads.
- primary_references
- [dhc-p29590555] Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate. (2018). https://pubmed.ncbi.nlm.nih.gov/29590555/ DOI: 10.1152/ajpregu.00049.2018
- tissue_or_cell_type
- Nucleus tractus solitarius and brown adipose tissue
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Urethane-chloralose-anaesthetised rats with nucleus tractus solitarius nanoinjection, sympathetic nerve recording and vagotomy · source_derived_draft · unverified_draft
### dhc-not-a-vagal-route Bilateral cervical or subdiaphragmatic vagotomy attenuated the decreases in brown adipose tissue sympathetic nerve activity and thermogenesis evoked by nanoinjection of resiniferatoxin into the nucleus tractus solitarius but did not prevent the decreases evoked by intravenous dihydrocapsaicin, consistent with a non-vagal pathway through which systemic TRPV1 agonists can inhibit brown adipose tissue thermogenesis. Condition category: normal nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Cutting the vagus nerve stopped the brain-injected agonist working but not the injected one, so they reach the heater by different roads. organism: Rat tissue_or_cell_type: Nucleus tractus solitarius and brown adipose tissue experimental_model: Urethane-chloralose-anaesthetised rats with nucleus tractus solitarius nanoinjection, sympathetic nerve recording and vagotomy limitations: The vagotomy control separates a central vagal route from whatever systemic dihydrocapsaicin uses. Anaesthetised animals, so the cardiovascular numbers are not directly comparable with the conscious studies here. exposure: Intravenous dihydrocapsaicin, against resiniferatoxin nanoinjected into the nucleus tractus solitarius, with capsazepine and bilateral cervical or subdiaphragmatic vagotomy evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/29590555.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "947ba9408e8bbaecee08ba0b2018014faa1d26d3c1fdf8df063e92911e53e19a", "start_char": 0, "end_char": 1882, "text_sha256": "947ba9408e8bbaecee08ba0b2018014faa1d26d3c1fdf8df063e92911e53e19a"} [dhc-p29590555] Activation of TRPV1 in nucleus tractus solitarius reduces brown adipose tissue thermogenesis, arterial pressure, and heart rate. (2018). https://pubmed.ncbi.nlm.nih.gov/29590555/ DOI: 10.1152/ajpregu.00049.2018
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.