Component
Urine flow rate
Independent biological entity. Read linked claims for experimental scope and context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Furosemide and saline interventions increased urinary thiamine loss in six volunteers; excretion tracked urine flow without an additional intervention-type effect.
Experimental context and source evidence
- cross_nutrient
- Diuresis links vitamin loss with renal electrolyte management.
- experimental_model
- Timed crossover physiologic measurements.
- exposure
- Single intravenous furosemide doses 1, 3 and 10 mg, and a separate 750 mL saline infusion; acute physiologic study exposures.
- limitations
- Acute small study; cannot predict chronic deficiency for every diuretic user or infer a universal flow threshold.
- nutrient_topic
- Thiamine research collection; topical membership is not evidence of a direct dietary effect. · Thiamine (vitamin B1)
- organism
- Homo sapiens
- plain_language
- Producing more urine can increase B1 loss even without a unique drug-specific mechanism.
- primary_references
- [b1-rieck1999] Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers (1999). https://pubmed.ncbi.nlm.nih.gov/10482308/ DOI: 10.1016/s0022-2143(99)90203-2
- tissue_or_cell_type
- Urine
Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 1720–1731
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Timed crossover physiologic measurements. · source_derived_draft · unverified_draft
### b1-diuresis-urinary-loss Furosemide and saline interventions increased urinary thiamine loss in six volunteers; excretion tracked urine flow without an additional intervention-type effect. Condition category: normal nutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Producing more urine can increase B1 loss even without a unique drug-specific mechanism. organism: Homo sapiens tissue_or_cell_type: Urine experimental_model: Timed crossover physiologic measurements. limitations: Acute small study; cannot predict chronic deficiency for every diuretic user or infer a universal flow threshold. cross_nutrient: Diuresis links vitamin loss with renal electrolyte management. exposure: Single intravenous furosemide doses 1, 3 and 10 mg, and a separate 750 mL saline infusion; acute physiologic study exposures. [b1-rieck1999] Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers (1999). https://pubmed.ncbi.nlm.nih.gov/10482308/ DOI: 10.1016/s0022-2143(99)90203-2
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.