{"id":"496e7933-fbb6-57da-892b-dfbff49c6486","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-diuresis-urinary-loss","predicate":"increases_with","statement":"Furosemide and saline interventions increased urinary thiamine loss in six volunteers; excretion tracked urine flow without an additional intervention-type effect.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c511f186-321f-5004-a6d2-7a948f6d7743","mechanism_event_label":"Producing more urine can increase B1 loss even without a unique drug-specific mechanism.","subject":{"id":"386c737b-9c01-528a-995a-f16b1e7befc7","slug":"urine-flow-rate","display_name":"Urine flow rate","entity_type_key":"cellular_process"},"object":{"id":"b64e359c-3dc6-5146-ab61-768deb93680e","slug":"urinary-thiamine-excretion","display_name":"Urinary thiamine excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c511f186-321f-5004-a6d2-7a948f6d7743","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-diuresis-urinary-loss-event","event_type":"observed_intervention","label":"Producing more urine can increase B1 loss even without a unique drug-specific mechanism.","description":"Furosemide and saline interventions increased urinary thiamine loss in six volunteers; excretion tracked urine flow without an additional intervention-type effect.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d16fc9af-92d1-5d7a-bf37-404403e0dd7e","slug":"furosemide","display_name":"Furosemide","entity_type_key":"small_molecule"},"role":"tested_drug","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"excreted_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"measured_parallel_electrolyte","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"386c737b-9c01-528a-995a-f16b1e7befc7","slug":"urine-flow-rate","display_name":"Urine flow rate","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b64e359c-3dc6-5146-ab61-768deb93680e","slug":"urinary-thiamine-excretion","display_name":"Urinary thiamine excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Diuresis links vitamin loss with renal electrolyte management.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Timed crossover physiologic measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Single intravenous furosemide doses 1, 3 and 10 mg, and a separate 750 mL saline infusion; acute physiologic study exposures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute small study; cannot predict chronic deficiency for every diuretic user or infer a universal flow threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Producing more urine can increase B1 loss even without a unique drug-specific mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b1-rieck1999] Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers (1999). https://pubmed.ncbi.nlm.nih.gov/10482308/ DOI: 10.1016/s0022-2143(99)90203-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a0325a06-f4ab-5927-9dbc-41fd48afb49a","evidence_kind":"source_excerpt","locator":"Lines 1720-1731","start_line":1720,"end_line":1731,"excerpt":"### b1-diuresis-urinary-loss\nFurosemide and saline interventions increased urinary thiamine loss in six volunteers; excretion tracked urine flow without an additional intervention-type effect.\nCondition category: normal\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Producing more urine can increase B1 loss even without a unique drug-specific mechanism.\norganism: Homo sapiens\ntissue_or_cell_type: Urine\nexperimental_model: Timed crossover physiologic measurements.\nlimitations: Acute small study; cannot predict chronic deficiency for every diuretic user or infer a universal flow threshold.\ncross_nutrient: Diuresis links vitamin loss with renal electrolyte management.\nexposure: Single intravenous furosemide doses 1, 3 and 10 mg, and a separate 750 mL saline infusion; acute physiologic study exposures.\n[b1-rieck1999] Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers (1999). https://pubmed.ncbi.nlm.nih.gov/10482308/ DOI: 10.1016/s0022-2143(99)90203-2","model_system":"Timed crossover physiologic measurements.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b1-rieck1999] Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers (1999). https://pubmed.ncbi.nlm.nih.gov/10482308/ DOI: 10.1016/s0022-2143(99)90203-2","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}