Component
Urinary stone incidence
Process or measured study endpoint, not a chemical species; outcome definition is retained in claim context.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
WHI assigned calcium plus vitamin D increased reported renal-calculus events relative to placebo.
Experimental context and source evidence
- experimental_model
- Randomized WHI safety outcome.
- exposure
- Renal-calculus HR 1.17, 95% CI 1.02-1.34; same assigned regimen as the fracture analysis.
- limitations
- Combined intervention; cannot attribute the whole effect to calcium or identify every stone composition.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Homo sapiens
- plain_language
- The same trial recorded more kidney-stone events with the combined supplements.
- primary_references
- [cal-clin-jackson2006] Calcium plus vitamin D supplementation and the risk of fractures (2006). https://pubmed.ncbi.nlm.nih.gov/16481635/ DOI: 10.1056/NEJMoa055218
- tissue_or_cell_type
- Human clinical or absorption endpoint
Calcium: mechanism-first literature curation (2026-09-17) · lines 1223–1233
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized WHI safety outcome. · source_derived_draft · unverified_draft
### cal-whi-urinary-stones WHI assigned calcium plus vitamin D increased reported renal-calculus events relative to placebo. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The same trial recorded more kidney-stone events with the combined supplements. organism: Homo sapiens tissue_or_cell_type: Human clinical or absorption endpoint experimental_model: Randomized WHI safety outcome. limitations: Combined intervention; cannot attribute the whole effect to calcium or identify every stone composition. exposure: Renal-calculus HR 1.17, 95% CI 1.02-1.34; same assigned regimen as the fracture analysis. [cal-clin-jackson2006] Calcium plus vitamin D supplementation and the risk of fractures (2006). https://pubmed.ncbi.nlm.nih.gov/16481635/ DOI: 10.1056/NEJMoa055218
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.