Component
Urinary F2-isoprostanes in the 2011 oral-GSH trial
Urinary F2-isoprostanes in the 2011 oral-GSH trial. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The between-group change in urinary F2-isoprostanes was not significant (p=0.38).
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/glutathione-research/21875351.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d6f87d899397204e2bfb9a70e2262ccdd14364350668fbb50906662149fc4f69", "start_char": 0, "end_char": 2042, "text_sha256": "d6f87d899397204e2bfb9a70e2262ccdd14364350668fbb50906662149fc4f69"}
- experimental_model
- Randomized double-blind placebo-controlled trial
- exposure
- GSH 500 mg twice daily for four weeks
- limitations
- Trial-specific null results; not proof that every dose, duration or formulation is inactive.
- nutrient_topic
- Glutathione research collection; topical membership is not evidence of a direct dietary effect. · GSH
- organism
- Human
- plain_language
- The tested supplement did not improve this measured endpoint.
- primary_references
- [glutathione-p21875351] Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. (2011). https://pubmed.ncbi.nlm.nih.gov/21875351/ DOI: 10.1089/acm.2010.0716
- tissue_or_cell_type
- 40 healthy adults; 39 completed
Glutathione: metabolism, signaling and nutrient connections (2026-09-17) · lines 1152–1163
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial · source_derived_draft · unverified_draft
### glutathione-oral-2011-isoprostane-null The between-group change in urinary F2-isoprostanes was not significant (p=0.38). Condition category: normal nutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect. plain_language: The tested supplement did not improve this measured endpoint. organism: Human tissue_or_cell_type: 40 healthy adults; 39 completed experimental_model: Randomized double-blind placebo-controlled trial limitations: Trial-specific null results; not proof that every dose, duration or formulation is inactive. exposure: GSH 500 mg twice daily for four weeks evidence_span: {"source_cache": "artifacts/glutathione-research/21875351.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d6f87d899397204e2bfb9a70e2262ccdd14364350668fbb50906662149fc4f69", "start_char": 0, "end_char": 2042, "text_sha256": "d6f87d899397204e2bfb9a70e2262ccdd14364350668fbb50906662149fc4f69"} [glutathione-p21875351] Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. (2011). https://pubmed.ncbi.nlm.nih.gov/21875351/ DOI: 10.1089/acm.2010.0716
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.