{"id":"03a991bc-a602-539f-a843-6edb877f781d","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-oral-2011-isoprostane-null","predicate":"has_no_significant_effect","statement":"The between-group change in urinary F2-isoprostanes was not significant (p=0.38).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"86f14bf6-2ef1-5fd3-8779-40a86f21526e","mechanism_event_label":"The tested supplement did not improve this measured endpoint.","subject":{"id":"63e5d749-95b4-514b-8023-9bdabcd25003","slug":"oral-reduced-gsh-2011","display_name":"Oral reduced glutathione regimen in the 2011 trial","entity_type_key":"chemical_species"},"object":{"id":"33e3186d-17e9-5069-bcf3-9680b33273ff","slug":"urinary-f2-isoprostanes-2011","display_name":"Urinary F2-isoprostanes in the 2011 oral-GSH trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"86f14bf6-2ef1-5fd3-8779-40a86f21526e","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-oral-2011-isoprostane-null-event","event_type":"observed_intervention","label":"The tested supplement did not improve this measured endpoint.","description":"The between-group change in urinary F2-isoprostanes was not significant (p=0.38).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"supplemented_molecule","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"63e5d749-95b4-514b-8023-9bdabcd25003","slug":"oral-reduced-gsh-2011","display_name":"Oral reduced glutathione regimen in the 2011 trial","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"33e3186d-17e9-5069-bcf3-9680b33273ff","slug":"urinary-f2-isoprostanes-2011","display_name":"Urinary F2-isoprostanes in the 2011 oral-GSH trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glutathione-research/21875351.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d6f87d899397204e2bfb9a70e2262ccdd14364350668fbb50906662149fc4f69\", \"start_char\": 0, \"end_char\": 2042, \"text_sha256\": \"d6f87d899397204e2bfb9a70e2262ccdd14364350668fbb50906662149fc4f69\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"GSH 500 mg twice daily for four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Trial-specific null results; not proof that every dose, duration or formulation is inactive.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glutathione research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The tested supplement did not improve this measured endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[glutathione-p21875351] Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. 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