Component
Unchanged dihydrocapsaicin reaching trunk blood and brain
Unchanged dihydrocapsaicin reaching trunk blood and brain. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Tritiated dihydrocapsaicin and unlabelled capsaicin were readily absorbed from the gastrointestinal tract but were almost completely metabolized before reaching the general circulation, with less than 5% of total extracted radioactivity consisting of unchanged dihydrocapsaicin in trunk blood and brain 15 minutes after gastrointestinal application, against approximately 50% unchanged 3 minutes after intravenous or 90 minutes after subcutaneous application.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/dihydrocapsaicin-research/2280802.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "92a4527b69cd4c342da3d0aed850597ef4491122baf20b6a681e43ab0a8e2dd1", "start_char": 0, "end_char": 1280, "text_sha256": "92a4527b69cd4c342da3d0aed850597ef4491122baf20b6a681e43ab0a8e2dd1"}
- experimental_model
- Intragastric, intravenous and subcutaneous administration of tritiated dihydrocapsaicin in anaesthetised rats with tissue extraction
- exposure
- Tritiated dihydrocapsaicin and unlabelled capsaicin given intragastrically, intravenously or subcutaneously
- limitations
- The comparison across routes is the point, and it is the reason every hypothermia study in this collection injects the drug rather than feeding it. Anaesthetised rats, and identification is chromatographic.
- nutrient_topic
- Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. · Dihydrocapsaicin
- organism
- Rat
- plain_language
- Swallowed, almost none of it reaches the brain intact; injected, about half does.
- primary_references
- [dhc-p2280802] Absorption and metabolism of capsaicinoids following intragastric administration in rats. (1990). https://pubmed.ncbi.nlm.nih.gov/2280802/ DOI: 10.1007/bf00169449
- tissue_or_cell_type
- Portal blood, trunk blood, brain and liver
- trigger_kind
- biomarker_context Imported condition classification; unverified.
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Intragastric, intravenous and subcutaneous administration of tritiated dihydrocapsaicin in anaesthetised rats with tissue extraction · source_derived_draft · unverified_draft
### dhc-first-pass-destroys-it Tritiated dihydrocapsaicin and unlabelled capsaicin were readily absorbed from the gastrointestinal tract but were almost completely metabolized before reaching the general circulation, with less than 5% of total extracted radioactivity consisting of unchanged dihydrocapsaicin in trunk blood and brain 15 minutes after gastrointestinal application, against approximately 50% unchanged 3 minutes after intravenous or 90 minutes after subcutaneous application. Condition category: biomarker_context nutrient_topic: Dihydrocapsaicin research collection; topical membership is not evidence of a direct clinical effect, and dihydrocapsaicin is recorded separately from capsaicin. plain_language: Swallowed, almost none of it reaches the brain intact; injected, about half does. organism: Rat tissue_or_cell_type: Portal blood, trunk blood, brain and liver experimental_model: Intragastric, intravenous and subcutaneous administration of tritiated dihydrocapsaicin in anaesthetised rats with tissue extraction limitations: The comparison across routes is the point, and it is the reason every hypothermia study in this collection injects the drug rather than feeding it. Anaesthetised rats, and identification is chromatographic. exposure: Tritiated dihydrocapsaicin and unlabelled capsaicin given intragastrically, intravenously or subcutaneously evidence_span: {"source_cache": "artifacts/dihydrocapsaicin-research/2280802.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "92a4527b69cd4c342da3d0aed850597ef4491122baf20b6a681e43ab0a8e2dd1", "start_char": 0, "end_char": 1280, "text_sha256": "92a4527b69cd4c342da3d0aed850597ef4491122baf20b6a681e43ab0a8e2dd1"} [dhc-p2280802] Absorption and metabolism of capsaicinoids following intragastric administration in rats. (1990). https://pubmed.ncbi.nlm.nih.gov/2280802/ DOI: 10.1007/bf00169449
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.