Component
Human thymidylate synthase / TYMS
Homo sapiens protein; gene perturbations are separate gene entities.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human TYMS uses 5,10-methylene-THF to convert dUMP to dTMP, producing dihydrofolate.
Experimental context and source evidence
- experimental_model
- Purified human TYMS reaction assays
- exposure
- Assay conditions described in the linked primary study.
- limitations
- Purified-enzyme chemistry does not specify cellular flux.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- Folate supplies the carbon and reducing power to make a DNA base.
- primary_references
- [islam-2018] Bacterial versus human thymidylate synthase: Kinetics and functionality (2018). https://pubmed.ncbi.nlm.nih.gov/29715278/ DOI: 10.1371/journal.pone.0196506
- tissue_or_cell_type
- Cell-free
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 973–983
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified human TYMS reaction assays · source_derived_draft · unverified_draft
### tyms-dump-methylation Human TYMS uses 5,10-methylene-THF to convert dUMP to dTMP, producing dihydrofolate. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Folate supplies the carbon and reducing power to make a DNA base. organism: Homo sapiens tissue_or_cell_type: Cell-free experimental_model: Purified human TYMS reaction assays limitations: Purified-enzyme chemistry does not specify cellular flux. exposure: Assay conditions described in the linked primary study. [islam-2018] Bacterial versus human thymidylate synthase: Kinetics and functionality (2018). https://pubmed.ncbi.nlm.nih.gov/29715278/ DOI: 10.1371/journal.pone.0196506
Complete structured claim and evidence
What acts on it
Added magnesium did not enhance human TYMS reaction rates under conditions where bacterial TYMS differed.
Experimental context and source evidence
- cross_nutrient
- Species-specific boundary on a proposed magnesium-folate interaction.
- experimental_model
- Comparative enzyme kinetics
- exposure
- Assay conditions described in the linked primary study.
- limitations
- Assay-specific negative result, not proof of magnesium-independent DNA synthesis.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- Magnesium effects on bacterial enzymes cannot be assumed for human TYMS.
- primary_references
- [islam-2018] Bacterial versus human thymidylate synthase: Kinetics and functionality (2018). https://pubmed.ncbi.nlm.nih.gov/29715278/ DOI: 10.1371/journal.pone.0196506
- tissue_or_cell_type
- Cell-free
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 985–996
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Comparative enzyme kinetics · source_derived_draft · unverified_draft
### human-tyms-magnesium-not-stimulatory Added magnesium did not enhance human TYMS reaction rates under conditions where bacterial TYMS differed. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Magnesium effects on bacterial enzymes cannot be assumed for human TYMS. organism: Homo sapiens tissue_or_cell_type: Cell-free experimental_model: Comparative enzyme kinetics limitations: Assay-specific negative result, not proof of magnesium-independent DNA synthesis. exposure: Assay conditions described in the linked primary study. cross_nutrient: Species-specific boundary on a proposed magnesium-folate interaction. [islam-2018] Bacterial versus human thymidylate synthase: Kinetics and functionality (2018). https://pubmed.ncbi.nlm.nih.gov/29715278/ DOI: 10.1371/journal.pone.0196506
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.