Component
Human alpha-TTP R221W
Human alpha-TTP carrying the AVED-associated Arg221Trp substitution.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Human TTP(R221W) remained punctate after alpha-tocopherol treatment in rat McARH7777 cells, unlike wild-type TTP.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- cross_nutrient
- false
- experimental_model
- Human wild-type versus R221W TTP expression; Figure 2B
- exposure
- 35 µM serum-complexed alpha-tocopherol for 24 hours after medium depletion.
- limitations
- Mutation contrast is machinery impairment; this does not establish that supplementation cannot help AVED clinically.
- nutrient_topic
- Vitamin E research collection; topical membership is not evidence of a direct dietary effect. · Vitamin E
- organism
- Human proteins in Rattus norvegicus cells
- plain_language
- An AVED-associated variant failed to change location when vitamin E was supplied.
- primary_references
- [chung2016] Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein. (2016). https://pubmed.ncbi.nlm.nih.gov/27307040/ DOI: 10.1074/jbc.m116.734210
- tissue_or_cell_type
- Hepatoma cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17) · lines 350–361
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Human wild-type versus R221W TTP expression; Figure 2B · source_derived_draft · unverified_draft
### ve-transport-r221w-localization Human TTP(R221W) remained punctate after alpha-tocopherol treatment in rat McARH7777 cells, unlike wild-type TTP. Condition category: machinery_impairment nutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect. plain_language: An AVED-associated variant failed to change location when vitamin E was supplied. organism: Human proteins in Rattus norvegicus cells tissue_or_cell_type: Hepatoma cells experimental_model: Human wild-type versus R221W TTP expression; Figure 2B limitations: Mutation contrast is machinery impairment; this does not establish that supplementation cannot help AVED clinically. exposure: 35 µM serum-complexed alpha-tocopherol for 24 hours after medium depletion. cross_nutrient: false [chung2016] Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein. (2016). https://pubmed.ncbi.nlm.nih.gov/27307040/ DOI: 10.1074/jbc.m116.734210
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.