Component
Human TRPM2
Human calcium-permeable cation channel; historically LTRPC2.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Intracellular free ADP-ribose gated calcium-permeable currents in HEK293 cells expressing human TRPM2/LTRPC2.
Experimental context and source evidence
- cross_nutrient
- true
- evidence_span
- {"source_cache": "artifacts/niacin-consumption-sources/trpm2001.abstract.txt", "locator": "Indexed abstract", "start_char": 0, "end_char": 964, "file_sha256": "960106d86cb7e891772139bf3b6339a1e50129c93a9e3517ebc7b86d61b4178e", "text_sha256": "960106d86cb7e891772139bf3b6339a1e50129c93a9e3517ebc7b86d61b4178e"}
- experimental_model
- Whole-cell and single-channel electrophysiology
- exposure
- Intracellular free ADP-ribose
- limitations
- This establishes channel gating in the assay, not that all NAD cleavage causes calcium influx in vivo.
- nutrient_topic
- Niacin research collection; topical membership is not evidence of a direct dietary effect. · Niacin (vitamin B3)
- organism
- Human
- plain_language
- Free ADP-ribose can open a channel that conducts calcium.
- primary_references
- [b3-cons-trpm2001] ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (2001). https://pubmed.ncbi.nlm.nih.gov/11385575/ DOI: 10.1038/35079100
- tissue_or_cell_type
- HEK293 cells expressing recombinant TRPM2
Niacin: NAD metabolism, deficiency and nutrient interactions (2026-09-17) · lines 621–633
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Whole-cell and single-channel electrophysiology · source_derived_draft · unverified_draft
### b3-cons-adpr-trpm2-gating Intracellular free ADP-ribose gated calcium-permeable currents in HEK293 cells expressing human TRPM2/LTRPC2. Condition category: normal nutrient_topic: Niacin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Free ADP-ribose can open a channel that conducts calcium. organism: Human tissue_or_cell_type: HEK293 cells expressing recombinant TRPM2 experimental_model: Whole-cell and single-channel electrophysiology limitations: This establishes channel gating in the assay, not that all NAD cleavage causes calcium influx in vivo. exposure: Intracellular free ADP-ribose cross_nutrient: true evidence_span: {"source_cache": "artifacts/niacin-consumption-sources/trpm2001.abstract.txt", "locator": "Indexed abstract", "start_char": 0, "end_char": 964, "file_sha256": "960106d86cb7e891772139bf3b6339a1e50129c93a9e3517ebc7b86d61b4178e", "text_sha256": "960106d86cb7e891772139bf3b6339a1e50129c93a9e3517ebc7b86d61b4178e"} [b3-cons-trpm2001] ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. (2001). https://pubmed.ncbi.nlm.nih.gov/11385575/ DOI: 10.1038/35079100
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.