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(2001). https://pubmed.ncbi.nlm.nih.gov/11385575/ DOI: 10.1038/35079100","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HEK293 cells expressing recombinant TRPM2","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c45d6ce3-81dd-551d-ac6c-ada79c2c33fb","evidence_kind":"source_excerpt","locator":"Lines 621-633","start_line":621,"end_line":633,"excerpt":"### b3-cons-adpr-trpm2-gating\nIntracellular free ADP-ribose gated calcium-permeable currents in HEK293 cells expressing human TRPM2/LTRPC2.\nCondition category: normal\nnutrient_topic: Niacin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Free ADP-ribose can open a channel that conducts calcium.\norganism: Human\ntissue_or_cell_type: HEK293 cells expressing recombinant TRPM2\nexperimental_model: Whole-cell and single-channel electrophysiology\nlimitations: This establishes channel gating in the assay, not that all NAD cleavage causes calcium influx in vivo.\nexposure: Intracellular free ADP-ribose\ncross_nutrient: true\nevidence_span: {\"source_cache\": \"artifacts/niacin-consumption-sources/trpm2001.abstract.txt\", \"locator\": \"Indexed abstract\", \"start_char\": 0, \"end_char\": 964, \"file_sha256\": \"960106d86cb7e891772139bf3b6339a1e50129c93a9e3517ebc7b86d61b4178e\", \"text_sha256\": \"960106d86cb7e891772139bf3b6339a1e50129c93a9e3517ebc7b86d61b4178e\"}\n[b3-cons-trpm2001] ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. 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